FFN 511

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Cat.No. 3878 - FFN 511 | C17H20N2O2 | CAS No. 1004548-96-2
Description: Fluorescent substrate for VMAT2
Chemical Name: 9-(2-Aminoethyl)-2,3,6,7-tetrahydro-1H,5H,11H-[1]-benzopyrano[6,7,8-ij]quinolizin-11-one
Purity: ≥99% (HPLC)

Biological Activity

Fluorescent false neurotransmitter (FFN). Targets neuronal vesicular monoamine transporter (VMAT) 2; inhibits serotonin binding to VMAT2 (IC50 = 1 μM). Excitation and emission maxima are 406 and 501 nm in pH 7 buffer, respectively.

Licensing Information

Sold with the permission of Columbia University

Technical Data

M. Wt 284.35
Formula C17H20N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1004548-96-2
PubChem ID 23725121
Smiles NCCC(C1=C(O4)C3=C2C(CCCN2CCC3)=C1)=CC4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 7.11 25
DMSO 1.42 5

Preparing Stock Solutions

The following data is based on the product molecular weight 284.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 14.07 mL 70.34 mL 140.67 mL
1.25 mM 2.81 mL 14.07 mL 28.13 mL
2.5 mM 1.41 mL 7.03 mL 14.07 mL
12.5 mM 0.28 mL 1.41 mL 2.81 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Gubernator et al (2009) Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. Science 324 1441 PMID: 19423778

Zhang et al (2009) Dopamine release at individual presynaptic terminals visualized with FFNs. J.Vis.Exp. 30 PMID: 19721412

If you know of a relevant reference for FFN 511, please let us know.

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