FFN 206 dihydrochloride

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Cat.No. 5043 - FFN 206 dihydrochloride | C12H14N2O2.2HCl | CAS No. 1883548-88-6
Description: Fluorescent VMAT2 substrate
Chemical Name: 4-(2-Aminoethyl)-7-(methylamino)-2H-1-benzopyran-2-one dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Fluorescent VMAT2 substrate (IC50 app = 1.15 μM). Allows detection of VMAT2 subcellular locations in cell culture. Exhibits no detectable inhibition of DAT. Excitation maximum = 369 nm; emission maximum = 464 nm.

Licensing Information

Sold with the permission of Columbia University

Technical Data

M. Wt 291.17
Formula C12H14N2O2.2HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1883548-88-6
PubChem ID 91826079
InChI Key ODENAPXTSFPACZ-UHFFFAOYSA-N
Smiles CNC1=CC=C2C(OC(C=C2CCN)=O)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.56 50
water 29.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 291.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.17 mL 34.34 mL
5 mM 0.69 mL 3.43 mL 6.87 mL
10 mM 0.34 mL 1.72 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hu et al (2013) New fluorescent substrate enables quantitative and high-throughput examination of vesicular monoamine transporter 2 (VMAT2). ACS Chem.Biol. 8 1947 PMID: 23859623


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Keywords: FFN206 dihydrochloride Fluorescent VMAT2 substrates vesicular monoamine transporters Fluorescent Probes

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New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

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