FFN 206 dihydrochloride

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Description: Fluorescent VMAT2 substrate
Chemical Name: 4-(2-Aminoethyl)-7-(methylamino)-2H-1-benzopyran-2-one dihydrochloride
Purity: ≥99% (HPLC)
Citations (2)
Literature (1)

Biological Activity for FFN 206 dihydrochloride

FFN 206 dihydrochloride is a fluorescent VMAT2 substrate (IC50 app = 1.15 μM). Allows detection of VMAT2 subcellular locations in cell culture. Exhibits no detectable inhibition of DAT. Excitation maximum = 369 nm; emission maximum = 464 nm.

Licensing Information

Sold with the permission of Columbia University

Optical Data for FFN 206 dihydrochloride

FFN 206 dihydrochloride Dye Spectra
Emission Color Blue
λabs 369 nm
λem 464 nm
Application Fluorescence Microscopy, Confocal Microscopy

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Technical Data for FFN 206 dihydrochloride

M. Wt 291.17
Formula C12H14N2O2.2HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1883548-88-6
PubChem ID 91826079
Smiles CNC1=CC=C2C(OC(C=C2CCN)=O)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FFN 206 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 29.12 100
DMSO 14.56 50

Preparing Stock Solutions for FFN 206 dihydrochloride

The following data is based on the product molecular weight 291.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.17 mL 34.34 mL
5 mM 0.69 mL 3.43 mL 6.87 mL
10 mM 0.34 mL 1.72 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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Product Datasheets for FFN 206 dihydrochloride

References for FFN 206 dihydrochloride

References are publications that support the biological activity of the product.

Hu et al (2013) New fluorescent substrate enables quantitative and high-throughput examination of vesicular monoamine transporter 2 (VMAT2). ACS Chem.Biol. 8 1947 PMID: 23859623

If you know of a relevant reference for FFN 206 dihydrochloride, please let us know.

Keywords: FFN 206 dihydrochloride, FFN 206 dihydrochloride supplier, FFN206, dihydrochloride, Fluorescent, VMAT2, substrates, vesicular, monoamine, transporters, Vesicular, Monoamine, Transporters, Substrates, Transporter, Probes, 5043, Tocris Bioscience

2 Citations for FFN 206 dihydrochloride

Citations are publications that use Tocris products. Selected citations for FFN 206 dihydrochloride include:

Simon C et al (2019) Drosophila Ptp4E regulates vesicular packaging for monoamine-neuropeptide co-transmission. J Cell Sci 132 PMID: 30837287

Hoffman et al (2018) Merkel cells activate sensory neural pathways through adrenergic synapses. Neuron 100 1401 PMID: 30415995

Do you know of a great paper that uses FFN 206 dihydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

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