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Submit ReviewFFN 206 dihydrochloride
Description: Fluorescent VMAT2 substrate
Chemical Name: 4-(2-Aminoethyl)-7-(methylamino)-2H-1-benzopyran-2-one dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity
Fluorescent VMAT2 substrate (IC50 app = 1.15 μM). Allows detection of VMAT2 subcellular locations in cell culture. Exhibits no detectable inhibition of DAT. Excitation maximum = 369 nm; emission maximum = 464 nm.
Licensing Information
Sold with the permission of Columbia University
Technical Data
| M. Wt | 291.17 |
| Formula | C12H14N2O2.2HCl |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1883548-88-6 |
| PubChem ID | 91826079 |
| InChI Key | ODENAPXTSFPACZ-UHFFFAOYSA-N |
| Smiles | CNC1=CC=C2C(OC(C=C2CCN)=O)=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 29.12 | 100 | |
| DMSO | 14.56 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 291.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.43 mL | 17.17 mL | 34.34 mL |
| 5 mM | 0.69 mL | 3.43 mL | 6.87 mL |
| 10 mM | 0.34 mL | 1.72 mL | 3.43 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.69 mL |
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References
References are publications that support the biological activity of the product.
Hu et al (2013) New fluorescent substrate enables quantitative and high-throughput examination of vesicular monoamine transporter 2 (VMAT2). ACS Chem.Biol. 8 1947 PMID: 23859623
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1 Citation for FFN 206 dihydrochloride
Citations are publications that use Tocris products. Selected citations for FFN 206 dihydrochloride include:
Hoffman et al (2018) Merkel cells activate sensory neural pathways through adrenergic synapses. Neuron 100 1401 PMID: 30415995
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