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FFN 206 dihydrochloride

Cat. No. 5043 1 Citation Submit a Review Datasheet / COA / SDS
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Cat.No. 5043 - FFN 206 dihydrochloride | C12H14N2O2.2HCl | CAS No. 1883548-88-6
Description: Fluorescent VMAT2 substrate
Chemical Name: 4-(2-Aminoethyl)-7-(methylamino)-2H-1-benzopyran-2-one dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Fluorescent VMAT2 substrate (IC50 app = 1.15 μM). Allows detection of VMAT2 subcellular locations in cell culture. Exhibits no detectable inhibition of DAT. Excitation maximum = 369 nm; emission maximum = 464 nm.

Licensing Information

Sold with the permission of Columbia University

Optical Data for FFN 206 dihydrochloride

FFN 206 dihydrochloride Dye Spectra
λabs 369 nm
λem 464 nm

Technical Data

M. Wt 291.17
Formula C12H14N2O2.2HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1883548-88-6
PubChem ID 91826079
InChI Key ODENAPXTSFPACZ-UHFFFAOYSA-N
Smiles CNC1=CC=C2C(OC(C=C2CCN)=O)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 29.12 100
DMSO 14.56 50

Preparing Stock Solutions

The following data is based on the product molecular weight 291.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.17 mL 34.34 mL
5 mM 0.69 mL 3.43 mL 6.87 mL
10 mM 0.34 mL 1.72 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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References

References are publications that support the biological activity of the product.

Hu et al (2013) New fluorescent substrate enables quantitative and high-throughput examination of vesicular monoamine transporter 2 (VMAT2). ACS Chem.Biol. 8 1947 PMID: 23859623

If you know of a relevant reference for FFN 206 dihydrochloride, please let us know.

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1 Citation for FFN 206 dihydrochloride

Citations are publications that use Tocris products. Selected citations for FFN 206 dihydrochloride include:

Hoffman et al (2018) Merkel cells activate sensory neural pathways through adrenergic synapses. Neuron 100 1401 PMID: 30415995

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Literature in this Area

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