Ferrostatin 1

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Cat.No. 5180 - Ferrostatin 1 | C15H22N2O2 | CAS No. 347174-05-4
Description: Selective inhibitor of erastin induced ferroptosis
Chemical Name: Ethyl 3-amino-4-(cyclohexylamino)benzoate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Selective inhibitor of erastin induced ferroptosis (EC50 = 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.

Compound Libraries

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Technical Data

M. Wt 262.35
Formula C15H22N2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 347174-05-4
PubChem ID 4068248
InChI Key UJHBVMHOBZBWMX-UHFFFAOYSA-N
Smiles O=C(OCC)C1=CC(N)=C(NC2CCCCC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.23 100
ethanol 26.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 262.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.81 mL 19.06 mL 38.12 mL
5 mM 0.76 mL 3.81 mL 7.62 mL
10 mM 0.38 mL 1.91 mL 3.81 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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References

References are publications that support the biological activity of the product.

Dixon et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149 1060 PMID: 22632970

Louandre et al (2013) Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib. Int.J.Cancer 133 1732 PMID: 23505071

Skouta et al (2014) Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J.Am.Chem.Soc. 136 4551 PMID: 24592866


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Citations for Ferrostatin 1

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer

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Pathways for Ferrostatin 1

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.