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Biological Activity for Ferrostatin 1
Ferrostatin 1 is a selective inhibitor of erastin induced ferroptosis (EC50 = 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.
Compound Libraries for Ferrostatin 1
Technical Data for Ferrostatin 1
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ferrostatin 1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Ferrostatin 1
The following data is based on the product molecular weight 262.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.81 mL||19.06 mL||38.12 mL|
|5 mM||0.76 mL||3.81 mL||7.62 mL|
|10 mM||0.38 mL||1.91 mL||3.81 mL|
|50 mM||0.08 mL||0.38 mL||0.76 mL|
References for Ferrostatin 1
References are publications that support the biological activity of the product.
Dixon et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149 1060 PMID: 22632970
Louandre et al (2013) Iron-dependent cell death of hepatocellular carcinoma cells exposed to sora. Int.J.Cancer 133 1732 PMID: 23505071
Skouta et al (2014) FerroSTAT inhibit oxidative lipid damage and cell death in diverse disease models. J.Am.Chem.Soc. 136 4551 PMID: 24592866
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Keywords: Ferrostatin 1, Ferrostatin 1 supplier, Selective, inhibitors, inhibits, erastin, induced, ferroptosis, RAS, selective, lethal, compound, RSL, ROS, Ferroptosis, 5180, Tocris Bioscience
1 Citation for Ferrostatin 1
Citations are publications that use Tocris products. Selected citations for Ferrostatin 1 include:
Bi et al (2019) Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis 10 682 PMID: 31527591
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Reviews for Ferrostatin 1
Average Rating: 5 (Based on 1 Review.)
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Combinatorial treatments of Ferrostatin 1 with other chemotherapeutic drugs were performed to elucidate the dependence of the latter on the induction of ferroptosis. Results were consistent.
Literature in this Area
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