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Biological Activity for Erastin
Erastin is an antitumor agent; selective for cells expressing oncogenic RAS. Activates ferroptosis; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.
Compound Libraries for Erastin
Technical Data for Erastin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Erastin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Erastin
The following data is based on the product molecular weight 547.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||9.14 mL||45.7 mL||91.4 mL|
|1 mM||1.83 mL||9.14 mL||18.28 mL|
|2 mM||0.91 mL||4.57 mL||9.14 mL|
|10 mM||0.18 mL||0.91 mL||1.83 mL|
References for Erastin
References are publications that support the biological activity of the product.
Dolma et al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3 285 PMID: 12676586
Yagoda et al (2007) RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447 864 PMID: 17568748
Dixon et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149 1060 PMID: 22632970
If you know of a relevant reference for Erastin, please let us know.
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2 Citations for Erastin
Citations are publications that use Tocris products. Selected citations for Erastin include:
Bi et al (2019) Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis 10 682 PMID: 31527591
Wei et al (2019) Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine. Nat Commun 10 3646 PMID: 31409778
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