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Description: Mitochondrial VDAC modulator; also Ferroptosis activator
Chemical Name: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
Purity: ≥98% (HPLC)
Citations (4)

Biological Activity for Erastin

Erastin is an antitumor agent; selective for cells expressing oncogenic RAS. Activates ferroptosis; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.

Compound Libraries for Erastin

Erastin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Erastin

M. Wt 547.04
Formula C30H31ClN4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 571203-78-6
PubChem ID 11214940
Smiles O=C2C1=CC=CC=C1N=C(C(N4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)C)N2C3=C(OCC)C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Erastin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 10.94 20

Preparing Stock Solutions for Erastin

The following data is based on the product molecular weight 547.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.14 mL 45.7 mL 91.4 mL
1 mM 1.83 mL 9.14 mL 18.28 mL
2 mM 0.91 mL 4.57 mL 9.14 mL
10 mM 0.18 mL 0.91 mL 1.83 mL

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Product Datasheets for Erastin

Certificate of Analysis / Product Datasheet
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References for Erastin

References are publications that support the biological activity of the product.

Dolma et al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3 285 PMID: 12676586

Yagoda et al (2007) RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447 864 PMID: 17568748

Dixon et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149 1060 PMID: 22632970

If you know of a relevant reference for Erastin, please let us know.

Keywords: Erastin, Erastin supplier, Synthetic, lethality, antitumor, agent, RAS-selective, lethal, synthetic, KRAS,, HRAS,, BRAF, small, T, ST, oncoprotiens, ferroptosis, activators, voltage-dependent, anion, channels, VDAC, Other, Channel, Modulators, Ferroptosis, 5449, Tocris Bioscience

4 Citations for Erastin

Citations are publications that use Tocris products. Selected citations for Erastin include:

Koki et al (2022) Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair. Cell Rep 41 111610 PMID: 36351395

Frank et al (2020) Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers. Cancer Res 80 1630-1643 PMID: 31911550

Wei et al (2019) Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine. Nat Commun 10 3646 PMID: 31409778

Bi et al (2019) Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis 10 682 PMID: 31527591

Do you know of a great paper that uses Erastin from Tocris? Please let us know.

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