Erastin

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Cat.No. 5449 - Erastin | C30H31ClN4O4 | CAS No. 571203-78-6
Description: Mitochondrial VDAC modulator; also Ferroptosis activator
Chemical Name: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Antitumor agent; selective for cells expressing oncogenic RAS. Also Ferroptosis activator; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.

Technical Data

M. Wt 547.04
Formula C30H31ClN4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 571203-78-6
PubChem ID 11214940
InChI Key BKQFRNYHFIQEKN-UHFFFAOYSA-N
Smiles O=C2C1=CC=CC=C1N=C(C(N4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)C)N2C3=C(OCC)C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.94 20

Preparing Stock Solutions

The following data is based on the product molecular weight 547.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.14 mL 45.7 mL 91.4 mL
1 mM 1.83 mL 9.14 mL 18.28 mL
2 mM 0.91 mL 4.57 mL 9.14 mL
10 mM 0.18 mL 0.91 mL 1.83 mL

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References

References are publications that support the biological activity of the product.

Dolma et al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3 285 PMID: 12676586

Yagoda et al (2007) RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447 864 PMID: 17568748

Dixon et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149 1060 PMID: 22632970


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Citations for Erastin

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New Product Guide (Spring/Summer 2018)

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