Erastin

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Cat.No. 5449 - Erastin | C30H31ClN4O4 | CAS No. 571203-78-6
Description: Mitochondrial VDAC modulator; also Ferroptosis activator
Chemical Name: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity

Antitumor agent; selective for cells expressing oncogenic RAS. Also Ferroptosis activator; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.

Technical Data

M. Wt 547.04
Formula C30H31ClN4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 571203-78-6
PubChem ID 11214940
InChI Key BKQFRNYHFIQEKN-UHFFFAOYSA-N
Smiles O=C2C1=CC=CC=C1N=C(C(N4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)C)N2C3=C(OCC)C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.94 20

Preparing Stock Solutions

The following data is based on the product molecular weight 547.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.14 mL 45.7 mL 91.4 mL
1 mM 1.83 mL 9.14 mL 18.28 mL
2 mM 0.91 mL 4.57 mL 9.14 mL
10 mM 0.18 mL 0.91 mL 1.83 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Dolma et al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3 285 PMID: 12676586

Yagoda et al (2007) RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447 864 PMID: 17568748

Dixon et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149 1060 PMID: 22632970


If you know of a relevant reference for Erastin, please let us know.

Keywords: Erastin, Erastin supplier, Synthetic, lethality, antitumor, agent, RAS-selective, lethal, synthetic, KRAS,, HRAS,, BRAF, small, T, ST, oncoprotiens, ferroptosis, activators, voltage-dependent, anion, channels, VDAC, Other, Channel, Modulators, Ferroptosis, 5449, Tocris Bioscience

2 Citations for Erastin

Citations are publications that use Tocris products. Selected citations for Erastin include:

Bi et al (2019) Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis 10 682 PMID: 31527591

Wei et al (2019) Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine. Nat Commun 10 3646 PMID: 31409778


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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New Product Guide [Spring/Summer 2019]

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