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Discontinued ProductFentanyl citrate (Cat. No. 3247) has been withdrawn from sale for commercial reasons.
Potent and selective μ-opioid receptor agonist (Ki values are 7.0, 151 and 470 nM for μ-, δ- and κ-opioid receptors respectively). Displays antinociceptive activity in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Zernig et al (1995) Receptor reserve and affinity of mu-opioid agonists in mouse antinociception: correlation with receptor binding. Life Sci. 57 2113 PMID: 7475964
Liu et al (2003) Opioid activity of C8813, a novel and potent opioid analgesic. Life Sci. 73 233 PMID: 12738037
Stevenson et al (2003) Opioid interactions in rhesus monkeys: effects of δ + μ and δ + κ agonists on schedule-controlled responding and thermal nociception. J.Pharmacol.Exp.Ther. 307 1054 PMID: 14557380
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.