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Submit ReviewETP 45835 dihydrochloride
Description: Mnk1 and Mnk2 inhibitor
Chemical Name: 4-[5-(4-Piperidinyl)-1H-pyrazol-3-yl]pyridine dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity
Mnk2 and Mnk1 inhibitor (IC50 values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein kinases, including those upstream of Mnk1/2.
Technical Data
| M. Wt | 301.21 |
| Formula | C13H16N4.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| PubChem ID | 71755761 |
| InChI Key | ASYCTHXAPLLLSZ-UHFFFAOYSA-N |
| Smiles | C1(C2=CC(C3=CC=NC=C3)=NN2)CCNCC1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.12 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 301.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.32 mL | 16.6 mL | 33.2 mL |
| 5 mM | 0.66 mL | 3.32 mL | 6.64 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Oyarzabal et al (2010) Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. J.Med.Chem. 53 6618 PMID: 20722422
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Keywords: ETP 45835 dihydrochloride, ETP 45835 dihydrochloride supplier, ETP45835, dihydrochloride, mitogen-activated, protein, kinase-interacting, kinase, Mnk1, Mnk2, inhibitors, inhibits, [791852-46-5], Mnk, 5183, Tocris Bioscience
1 Citation for ETP 45835 dihydrochloride
Citations are publications that use Tocris products. Selected citations for ETP 45835 dihydrochloride include:
Ichiyanagi et al (2019) Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma. Oncotarget 10 4053 PMID: 31258849
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Literature in this Area
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