ETP 45835 dihydrochloride

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Description: Mnk1 and Mnk2 inhibitor
Chemical Name: 4-[5-(4-Piperidinyl)-1H-pyrazol-3-yl]pyridine dihydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)

Biological Activity for ETP 45835 dihydrochloride

ETP 45835 dihydrochloride is a Mnk2 and Mnk1 inhibitor (IC50 values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein kinases, including those upstream of Mnk1/2.

Technical Data for ETP 45835 dihydrochloride

M. Wt 301.21
Formula C13H16N4.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 2136571-30-5
PubChem ID 71755761
Smiles C1(C2=CC(C3=CC=NC=C3)=NN2)CCNCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ETP 45835 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 30.12 100

Preparing Stock Solutions for ETP 45835 dihydrochloride

The following data is based on the product molecular weight 301.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.32 mL 16.6 mL 33.2 mL
5 mM 0.66 mL 3.32 mL 6.64 mL
10 mM 0.33 mL 1.66 mL 3.32 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets for ETP 45835 dihydrochloride

References for ETP 45835 dihydrochloride

References are publications that support the biological activity of the product.

Oyarzabal et al (2010) Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. J.Med.Chem. 53 6618 PMID: 20722422

If you know of a relevant reference for ETP 45835 dihydrochloride, please let us know.

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Keywords: ETP 45835 dihydrochloride, ETP 45835 dihydrochloride supplier, ETP45835, dihydrochloride, mitogen-activated, protein, kinase-interacting, kinase, Mnk1, Mnk2, inhibitors, inhibits, [791852-46-5], Mnk, 5183, Tocris Bioscience

1 Citation for ETP 45835 dihydrochloride

Citations are publications that use Tocris products. Selected citations for ETP 45835 dihydrochloride include:

Ichiyanagi et al (2019) Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma. Oncotarget 10 4053 PMID: 31258849

Do you know of a great paper that uses ETP 45835 dihydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.