ETP 45835 dihydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 5183 - ETP 45835 dihydrochloride | C13H16N4.2HCl
Description: Mnk1 and Mnk2 inhibitor
Chemical Name: 4-[5-(4-Piperidinyl)-1H-pyrazol-3-yl]pyridine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Mnk2 and Mnk1 inhibitor (IC50 values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein kinases, including those upstream of Mnk1/2.

Technical Data

M. Wt 301.21
Formula C13H16N4.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
PubChem ID 71755761
InChI Key ASYCTHXAPLLLSZ-UHFFFAOYSA-N
Smiles C1(C2=CC(C3=CC=NC=C3)=NN2)CCNCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 301.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.32 mL 16.6 mL 33.2 mL
5 mM 0.66 mL 3.32 mL 6.64 mL
10 mM 0.33 mL 1.66 mL 3.32 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Oyarzabal et al (2010) Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. J.Med.Chem. 53 6618 PMID: 20722422


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Keywords: ETP45835 dihydrochloride mitogen-activated protein kinase-interacting kinase Mnk1 Mnk2 inhibitors inhibits [791852-46-5] Mnk

Citations for ETP 45835 dihydrochloride

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for ETP 45835 dihydrochloride

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