ETP 45835 dihydrochloride

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Cat.No. 5183 - ETP 45835 dihydrochloride | C13H16N4.2HCl
Description: Mnk1 and Mnk2 inhibitor
Chemical Name: 4-[5-(4-Piperidinyl)-1H-pyrazol-3-yl]pyridine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Mnk2 and Mnk1 inhibitor (IC50 values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein kinases, including those upstream of Mnk1/2.

Technical Data

M. Wt 301.21
Formula C13H16N4.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
PubChem ID 71755761
InChI Key ASYCTHXAPLLLSZ-UHFFFAOYSA-N
Smiles C1(C2=CC(C3=CC=NC=C3)=NN2)CCNCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 301.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.32 mL 16.6 mL 33.2 mL
5 mM 0.66 mL 3.32 mL 6.64 mL
10 mM 0.33 mL 1.66 mL 3.32 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Oyarzabal et al (2010) Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. J.Med.Chem. 53 6618 PMID: 20722422


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Citations for ETP 45835 dihydrochloride

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Literature in this Area

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