ETP 45835 dihydrochloride

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Cat.No. 5183 - ETP 45835 dihydrochloride | C13H16N4.2HCl
Description: Mnk1 and Mnk2 inhibitor
Chemical Name: 4-[5-(4-Piperidinyl)-1H-pyrazol-3-yl]pyridine dihydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (3)

Biological Activity

Mnk2 and Mnk1 inhibitor (IC50 values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein kinases, including those upstream of Mnk1/2.

Technical Data

M. Wt 301.21
Formula C13H16N4.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
PubChem ID 71755761
Smiles C1(C2=CC(C3=CC=NC=C3)=NN2)CCNCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 30.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 301.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.32 mL 16.6 mL 33.2 mL
5 mM 0.66 mL 3.32 mL 6.64 mL
10 mM 0.33 mL 1.66 mL 3.32 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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References are publications that support the biological activity of the product.

Oyarzabal et al (2010) Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. J.Med.Chem. 53 6618 PMID: 20722422

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Keywords: ETP 45835 dihydrochloride, ETP 45835 dihydrochloride supplier, ETP45835, dihydrochloride, mitogen-activated, protein, kinase-interacting, kinase, Mnk1, Mnk2, inhibitors, inhibits, [791852-46-5], Mnk, 5183, Tocris Bioscience

1 Citation for ETP 45835 dihydrochloride

Citations are publications that use Tocris products. Selected citations for ETP 45835 dihydrochloride include:

Ichiyanagi et al (2019) Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma. Oncotarget 10 4053 PMID: 31258849

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cancer Research Product Guide

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Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.