ETP 45835 dihydrochloride
Biological Activity
Mnk2 and Mnk1 inhibitor (IC50 values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein kinases, including those upstream of Mnk1/2.
Technical Data
| M. Wt | 301.21 |
| Formula | C13H16N4.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| PubChem ID | 71755761 |
| InChI Key | ASYCTHXAPLLLSZ-UHFFFAOYSA-N |
| Smiles | C1(C2=CC(C3=CC=NC=C3)=NN2)CCNCC1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.12 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 301.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.32 mL | 16.6 mL | 33.2 mL |
| 5 mM | 0.66 mL | 3.32 mL | 6.64 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Oyarzabal et al (2010) Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. J.Med.Chem. 53 6618 PMID: 20722422
If you know of a relevant reference for ETP 45835 dihydrochloride, please let us know.
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Keywords: ETP45835 dihydrochloride mitogen-activated protein kinase-interacting kinase Mnk1 Mnk2 inhibitors inhibits [791852-46-5] Mnk
Citations for ETP 45835 dihydrochloride
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Literature in this Area
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
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Kinases Product Listing
A collection of over 400 products for kinase research, the listing includes inhibitors of:
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- PI-3 Kinase, Akt and mTOR
- MAPK Signaling
- Receptor Serine/Threonine Kinases
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
