ETP 45658

Discontinued Product

ETP 45658 (Cat. No. 4702) has been withdrawn from sale for commercial reasons.
Description: Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTOR
Chemical Name: 3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for ETP 45658

ETP 45658 is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively). Inhibits proliferation of multiple cancer cell lines in vitro and reduces Akt phosphorylation levels in vivo.

Technical Data for ETP 45658

M. Wt 311.34
Formula C16H17N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1198357-79-7
PubChem ID 25229608
Smiles CN2C1=NC(C3=CC(O)=CC=C3)=NC(N4CCOCC4)=C1C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: ETP 45658, ETP 45658 supplier, ETP45658, PI3-K, kinases, inhibitors, inhibits, dna-pk, mtor, PI3Ka, PI3Kalpha, PI3Kd, PI3Kdelta, PI3Kb, PI3Kbeta, PI3Kg, PI3Kgamma, PI3Kα, PI3Kδ, PI3Kβ, PI3Kγ, PI, 3-Kinase, mTOR, DNA-dependent, Protein, Kinase, 4702, Tocris Bioscience

2 Citations for ETP 45658

Citations are publications that use Tocris products. Selected citations for ETP 45658 include:

Small et al (2022) Phenotypic screening for small molecules that protect beta -cells from glucolipotoxicity. ACS Chem.Biol. 17 1131 PMID: 35439415

Maswadeh et al (2015) Coadministration of dox. and etop. loaded in camel milk phospholipids liposomes showed increased antitumor activity in a murine model. PLoS One 10 2847 PMID: 25926730

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