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Description: GABA-mimetic; selectively interacts with β2- and β3-subunit containing GABAA receptors
Chemical Name: (R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Citations (3)
Reviews (1)
Literature (2)

Biological Activity for Etomidate

Etomidate is a general anesthetic with GABA modulatory and GABA-mimetic actions; selectively interacts with β2- and β3-subunit containing GABAA receptors. Short acting and potent hypnotic, with low toxicity.

Technical Data for Etomidate

M. Wt 244.29
Formula C14H16N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 33125-97-2
PubChem ID 667484
Smiles O=C(OCC)C1=CN=CN1[C@@H]([C@@]2=CC=CC=C2)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Etomidate

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 24.43 100
1eq. HCl 12.21 50

Preparing Stock Solutions for Etomidate

The following data is based on the product molecular weight 244.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.09 mL 20.47 mL 40.93 mL
5 mM 0.82 mL 4.09 mL 8.19 mL
10 mM 0.41 mL 2.05 mL 4.09 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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References for Etomidate

References are publications that support the biological activity of the product.

Belelli et al (1997) The interaction of the general anesthetic EtoM. with the γ-aminobutyric acid type A receptor is influenced by a single amino acid. Proc.Natl.Acad.Sci.U.S.A. 94 11031 PMID: 9380754

Giese et al (1983) EtoM.: a new intravenous anesthetic induction agent. Pharmacother. 3 251 PMID: 6359080

Moody et al (1998) Distinct structural requirements for the direct and indirect actions of the anaesthetic EtoM. at GABAA receptors. Toxicol.Lett. 100-101 209 PMID: 10049144

If you know of a relevant reference for Etomidate, please let us know.

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Keywords: Etomidate, Etomidate supplier, GABA, mimetic, modulatory, agent, GABAA, Receptors, 1471, Tocris Bioscience

3 Citations for Etomidate

Citations are publications that use Tocris products. Selected citations for Etomidate include:

Olander et al (2018) Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors. Biochem.Pharmacol 150 305 PMID: 29454619

Rodgers et al (2015) EtoM. Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells. Proc Natl Acad Sci U S A 35 9707 PMID: 26134653

Drasbek et al (2007) Modulation of extrasynaptic THIP conductances by GABAA-receptor modulators in mouse neocortex. J Neurophysiol 97 2293 PMID: 17215511

Do you know of a great paper that uses Etomidate from Tocris? Please let us know.

Reviews for Etomidate

Average Rating: 5 (Based on 1 Review.)

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Would purchase again.
By Anonymous on 07/27/2022
Assay Type: In Vivo
Species: Mouse

We purchased this product and used it as anesthesia.

It came on time, amount was accurate. We would purchase again.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.