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Submit ReviewEtomidate
Description: GABA-mimetic; selectively interacts with β2- and β3-subunit containing GABAA receptors
Chemical Name: (R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Biological Activity
General anesthetic with GABA modulatory and GABA-mimetic actions; selectively interacts with β2- and β3-subunit containing GABAA receptors. Short acting and potent hypnotic, with low toxicity.
Technical Data
| M. Wt | 244.29 |
| Formula | C14H16N2O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 33125-97-2 |
| PubChem ID | 667484 |
| InChI Key | NPUKDXXFDDZOKR-LLVKDONJSA-N |
| Smiles | O=C(OCC)C1=CN=CN1[C@@H]([C@@]2=CC=CC=C2)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 24.43 | 100 | |
| 1eq. HCl | 12.21 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 244.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.09 mL | 20.47 mL | 40.93 mL |
| 5 mM | 0.82 mL | 4.09 mL | 8.19 mL |
| 10 mM | 0.41 mL | 2.05 mL | 4.09 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.82 mL |
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References
References are publications that support the biological activity of the product.
Belelli et al (1997) The interaction of the general anesthetic EtoM. with the γ-aminobutyric acid type A receptor is influenced by a single amino acid. Proc.Natl.Acad.Sci.U.S.A. 94 11031 PMID: 9380754
Giese et al (1983) EtoM.: a new intravenous anesthetic induction agent. Pharmacother. 3 251 PMID: 6359080
Moody et al (1998) Distinct structural requirements for the direct and indirect actions of the anaesthetic EtoM. at GABAA receptors. Toxicol.Lett. 100-101 209 PMID: 10049144
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Keywords: Etomidate, Etomidate supplier, GABA, mimetic, modulatory, agent, GABAA, Receptors, 1471, Tocris Bioscience
3 Citations for Etomidate
Citations are publications that use Tocris products. Selected citations for Etomidate include:
Olander et al (2018) Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors. Biochem.Pharmacol 150 305 PMID: 29454619
Rodgers et al (2015) EtoM. Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells. Proc Natl Acad Sci U S A 35 9707 PMID: 26134653
Drasbek et al (2007) Modulation of extrasynaptic THIP conductances by GABAA-receptor modulators in mouse neocortex. J Neurophysiol 97 2293 PMID: 17215511
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