Etomidate

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Cat.No. 1471 - Etomidate | C14H16N2O2 | CAS No. 33125-97-2
Description: GABA mimetic and GABA modulatory agent
Chemical Name: (R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

General anesthetic with GABA modulatory and GABA-mimetic actions; selectively interacts with β2- and β3-subunit containing GABAA receptors. Short acting and potent hypnotic, with low toxicity.

Technical Data

M. Wt 244.29
Formula C14H16N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 33125-97-2
PubChem ID 667484
InChI Key NPUKDXXFDDZOKR-LLVKDONJSA-N
Smiles O=C(OCC)C1=CN=CN1[C@@H]([C@@]2=CC=CC=C2)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 24.43 100
1eq. HCl 12.21 50

Preparing Stock Solutions

The following data is based on the product molecular weight 244.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.09 mL 20.47 mL 40.93 mL
5 mM 0.82 mL 4.09 mL 8.19 mL
10 mM 0.41 mL 2.05 mL 4.09 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Belelli et al (1997) The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid. Proc.Natl.Acad.Sci.U.S.A. 94 11031 PMID: 9380754

Giese et al (1983) Etomidate: a new intravenous anesthetic induction agent. Pharmacother. 3 251 PMID: 6359080

Moody et al (1998) Distinct structural requirements for the direct and indirect actions of the anaesthetic etomidate at GABAA receptors. Toxicol.Lett. 100-101 209 PMID: 10049144


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Keywords: Etomidate, Etomidate supplier, GABA, mimetic, modulatory, agent, GABAA, Receptors, 1471, Tocris Bioscience

3 Citations for Etomidate

Citations are publications that use Tocris products. Selected citations for Etomidate include:

Olander et al (2018) Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors. Biochem.Pharmacol 150 305 PMID: 29454619

Drasbek et al (2007) Modulation of extrasynaptic THIP conductances by GABAA-receptor modulators in mouse neocortex. J Neurophysiol 97 2293 PMID: 17215511

Rodgers et al (2015) Etomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells. Proc Natl Acad Sci U S A 35 9707 PMID: 26134653


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Literature in this Area

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*Please note that Tocris will only send literature to established scientific business / institute addresses.


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