ESI 09

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Cat.No. 4773 - ESI 09 | C16H15ClN4O2 | CAS No. 263707-16-0
Description: EPAC inhibitor
Chemical Name: α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

EPAC inhibitor. Inhibits EPAC-mediated insulin releases from pancreatic β cells. Selective for EPAC over PKA. Decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells in vitro.

Compound Libraries

ESI 09 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 330.77
Formula C16H15ClN4O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 263707-16-0
PubChem ID 6077765
InChI Key DXEATJQGQHDURZ-DEDYPNTBSA-N
Smiles CC(C)(C)C1=CC(C(/C(C#N)=N/NC2=CC=CC(Cl)=C2)=O)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.08 100
ethanol 6.62 20

Preparing Stock Solutions

The following data is based on the product molecular weight 330.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.12 mL 30.23 mL
5 mM 0.6 mL 3.02 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Almahariq et al (2013) A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol.Pharmacol. 83 122 PMID: 23066090


If you know of a relevant reference for ESI 09, please let us know.

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View all GTPase Inhibitors

Keywords: ESI09 EPAC exchange proteins inhibitors inhibits GTPases GTPase

1 Citation for ESI 09

Citations are publications that use Tocris products. Selected citations for ESI 09 include:

Wang et al (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. EMBO Mol Med 11 2057 PMID: 26649942


Do you know of a great paper that uses ESI 09 from Tocris? If so please let us know.

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Literature in this Area

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Pathways for ESI 09

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