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ESI 05 is an EPAC2 inhibitor. Inhibits cAMP binding to EPAC2 and cAMP mediated EPAC2 guanine nucleotide exchange factor (GEF) activity (IC50 = 0.4 μM).
ESI 05 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 274.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.64 mL||18.22 mL||36.45 mL|
|5 mM||0.73 mL||3.64 mL||7.29 mL|
|10 mM||0.36 mL||1.82 mL||3.64 mL|
|50 mM||0.07 mL||0.36 mL||0.73 mL|
References are publications that support the biological activity of the product.
Tsalkova et al (2012) Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc.Natl.Acad.Sci.USA. 109 18613 PMID: 23091014
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Keywords: ESI 05, ESI 05 supplier, ESI05, EPAC2, inhibitors, inhibits, EPAC, epac, exchange, proteins, directly, activated, by, cAMP, Rap, guanine, nucleotide, factor, 4, RAPGEF4, 6320, Tocris Bioscience
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