ESI 05

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Cat.No. 6320 - ESI 05 | C16H18O2S | CAS No. 5184-64-5
Description: EPAC2 inhibitor
Chemical Name: 1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

EPAC2 inhibitor. Inhibits cAMP binding to EPAC2 and cAMP mediated EPAC2 guanine nucleotide exchange factor (GEF) activity (IC50 = 0.4 μM).

Technical Data

M. Wt 274.38
Formula C16H18O2S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 5184-64-5
PubChem ID 272513
InChI Key CGPHOZWFSFNOEQ-UHFFFAOYSA-N
Smiles CC1=CC=C(S(=O)(C2=C(C=C(C=C2C)C)C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.44 100
ethanol 27.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 274.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.64 mL 18.22 mL 36.45 mL
5 mM 0.73 mL 3.64 mL 7.29 mL
10 mM 0.36 mL 1.82 mL 3.64 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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References

References are publications that support the biological activity of the product.

Tsalkova et al (2012) Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc.Natl.Acad.Sci.USA. 109 18613 PMID: 23091014


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Citations for ESI 05

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