Escitalopram oxalate

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Cat.No. 4796 - Escitalopram oxalate | C20H21FN2O.C2H2O4 | CAS No. 219861-08-2
Description: Selective serotonin reuptake inhibitor (SSRI)
Chemical Name: (+)-(S)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile oxalate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective 5-HT reuptake inhibitor (Ki values are 0.89, 8150, and 10500 nM for serotonin, noradrenalin, and dopamine transporters respectively). Is a S-enantiomer and eutomer of citalopram (Cat. No. 1427).

Compound Libraries

Escitalopram oxalate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 414.43
Formula C20H21FN2O.C2H2O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 219861-08-2
PubChem ID 146571
InChI Key KTGRHKOEFSJQNS-BDQAORGHSA-N
Smiles FC(C=C3)=CC=C3[C@]1(CCCN(C)C)OCC2=C1C=CC(C#N)=C2.OC(C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 20.72 50
DMSO 41.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 414.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.06 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Zhang et al (2010) Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. J.Med.Chem. 53 6112 PMID: 20672825


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Keywords: Escitalopram oxalate, Escitalopram oxalate supplier, Selective, serotonin, reuptake, inhibitors, inhibits, SSRI, SERT, 5-HT, Transporters, 4796, Tocris Bioscience

1 Citation for Escitalopram oxalate

Citations are publications that use Tocris products. Selected citations for Escitalopram oxalate include:

Lu et al (2016) Generation of serotonin neurons from human pluripotent stem cells. J Exp Med 34 89 PMID: 26655496


Do you know of a great paper that uses Escitalopram oxalate from Tocris? Please let us know.

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Literature in this Area

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.