Escitalopram oxalate

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Description: Selective serotonin reuptake inhibitor (SSRI)
Chemical Name: (+)-(S)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile oxalate
Purity: ≥98% (HPLC)
Citations (4)
Literature (1)

Biological Activity for Escitalopram oxalate

Escitalopram oxalate is a selective 5-HT reuptake inhibitor (Ki values are 0.89, 8150, and 10500 nM for serotonin, noradrenalin, and dopamine transporters respectively). Escitalopram oxalate is an S-enantiomer and eutomer of citalopram (Cat. No. 1427).

Compound Libraries for Escitalopram oxalate

Escitalopram oxalate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Escitalopram oxalate

M. Wt 414.43
Formula C20H21FN2O.C2H2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 219861-08-2
PubChem ID 146571
Smiles FC(C=C3)=CC=C3[C@]1(CCCN(C)C)OCC2=C1C=CC(C#N)=C2.OC(C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Escitalopram oxalate

Solvent Max Conc. mg/mL Max Conc. mM
water 20.72 50
DMSO 41.44 100

Preparing Stock Solutions for Escitalopram oxalate

The following data is based on the product molecular weight 414.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.06 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets for Escitalopram oxalate

Certificate of Analysis / Product Datasheet
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References for Escitalopram oxalate

References are publications that support the biological activity of the product.

Zhang et al (2010) Structure-activity relationships for a novel series of cital. (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. J.Med.Chem. 53 6112 PMID: 20672825

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Keywords: Escitalopram oxalate, Escitalopram oxalate supplier, Selective, serotonin, reuptake, inhibitors, inhibits, SSRI, SERT, 5-HT, Transporters, 4796, Tocris Bioscience

4 Citations for Escitalopram oxalate

Citations are publications that use Tocris products. Selected citations for Escitalopram oxalate include:

Henry A et al (2020) Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell 183 1986-2002.e26 PMID: 33333022

William C et al (2021) Psychedelic-inspired drug discovery using an engineered biosensor. Cell 184 2779-2792.e18 PMID: 33915107

Il-Whan et al (2017) Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells. Korean J Physiol Pharmacol 21 415-421 PMID: 28706455

Lu et al (2016) Generation of serotonin neurons from human pluripotent stem cells. J Exp Med 34 89 PMID: 26655496

Do you know of a great paper that uses Escitalopram oxalate from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.