Citalopram hydrobromide

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Cat.No. 1427 - Citalopram hydrobromide | C20H21FN2O.HBr | CAS No. 59729-32-7
Description: Highly potent and selective 5-HT uptake inhibitor
Chemical Name: 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
Purity: ≥99% (HPLC)
Datasheet
Citations (14)
Reviews
Literature

Biological Activity

Highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake (IC50 values are 1.8, 8800 and 41000 nM respectively). Has negligible activity at a wide range of receptors.

Deuterated analog also available.

Technical Data

M. Wt 405.31
Formula C20H21FN2O.HBr
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 59729-32-7
PubChem ID 77995
InChI Key WIHMBLDNRMIGDW-UHFFFAOYSA-N
Smiles Br.CN(C)CCCC1(OCC2=C1C=CC(=C2)C#N)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 50 mM in ethanol and to 10 mM in water

References

References are publications that support the biological activity of the product.

Auerbach and Hjorth (1995) Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo. Naunyn Schmiedebergs Arch.Pharmacol. 352 597 PMID: 9053730

Mateo et al (2000) Inhibition of 5-hydroxytryptamine reuptake by the antidepressant citalopram in the locus coeruleus modulates the rat brain noradrenergic transmission in vivo. Neuropharmacology 39 2036 PMID: 10963747

Hyttel (1982) Citalopram - pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog.Drug Metabolism. Eds. Bridges, J. W. & Ch 6 277


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Keywords: Citalopram hydrobromide, Citalopram hydrobromide supplier, potent, selective, 5-HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, 1427, Tocris Bioscience

14 Citations for Citalopram hydrobromide

Citations are publications that use Tocris products. Selected citations for Citalopram hydrobromide include:

Gasull-Camôs et al (2018) Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex. Neuropharmacology 139 41 PMID: 29940206

Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769

Jury et al (2015) Enhanced responsiveness to selective serotonin reuptake inhibitors during lactation. PLoS One 10 e0117339 PMID: 25689282

Morecroft et al (2010) In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Int J Neuropsychopharmacol 85 593 PMID: 19736308

Nolan et al (2014) Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporter. ACS Chem Neurosci 5 784 PMID: 25003748

Jiménez-Sánchez et al (2014) The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression. Neuropsychopharmacology 39 2673 PMID: 24871546

Murray et al (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med 16 694 PMID: 20512126

Maciag et al (2006) Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology 31 47 PMID: 16012532

Maciag et al (2006) Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development. Brain Res 1125 171 PMID: 17101120

Stuart et al (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38 1625 PMID: 23503126

Munari et al (2015) Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects. Psychopharmacology (Berl) 18 pyv045 PMID: 25899065

Phelps et al (2015) Psychopharmacological characterisation of the successive negative contrast effect in rats. Mol Ther 232 2697 PMID: 25791190

Morecroft et al (2012) Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension. PLoS One 20 1516 PMID: 22525513

Hutchinson et al (2012) Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. Cardiovasc Res 37 321 PMID: 21956448


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