Antibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC50 = 62.7 μM in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 579.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.72 mL||8.62 mL||17.24 mL|
|5 mM||0.34 mL||1.72 mL||3.45 mL|
|10 mM||0.17 mL||0.86 mL||1.72 mL|
|50 mM||0.03 mL||0.17 mL||0.34 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Cersosimo et al (1986) Epirubicin: a review of pharmacology, clinical activity, and adverse effects of an adriamycin analogue. J.Clin.Oncol. 4 425 PMID: 3005521
Spadari et al (1986) DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs. Anticancer Res. 6 935 PMID: 3026237
Schott and Robert (1989) Comparative activity of anthracycline 13-dihydrometabolites against rat glioblastoma cells in culture. Biochem.Pharmacol. 38 4069 PMID: 2597184
If you know of a relevant reference for Epirubicin hydrochloride, please let us know.
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Keywords: inhibitors inhibits DNA synthesis function topoisomerase II Isomerases antibiotics 4-Epidoxorubicin chemotherapeutics 4'-Epidoxorubicin DNA, RNA and Protein Synthesis
1 Citation for Epirubicin hydrochloride
Citations are publications that use Tocris products. Selected citations for Epirubicin hydrochloride include:
Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641 PMID: 24265703
Do you know of a great paper that uses Epirubicin hydrochloride from Tocris? If so please let us know.