Epirubicin hydrochloride

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Cat.No. 3260 - Epirubicin hydrochloride | C27H29NO11.HCl | CAS No. 56390-09-1
Description: Inhibits DNA synthesis and function. Inhibits DNA topoisomerase II
Alternative Names: 4'-Epidoxorubicin
Chemical Name: (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione hydrochloride
Purity: ≥96% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (1)

Biological Activity

Antibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC50 = 62.7 μM in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.

Technical Data

M. Wt 579.98
Formula C27H29NO11.HCl
Storage Desiccate at +4°C
Purity ≥96% (HPLC)
CAS Number 56390-09-1
PubChem ID 32874
InChI Key MWWSFMDVAYGXBV-FGBJBKNOSA-N
Smiles O=C(C2=C1C(OC)=CC=C2)C3=C(C(O)=C([C@](OC5CC(N)C(O)C(C)O5)([H])C[C@@]([C@@](CO)=O)(O)C4)C4=C3O)C1=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 58 100
water 29 50

Preparing Stock Solutions

The following data is based on the product molecular weight 579.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.72 mL 8.62 mL 17.24 mL
5 mM 0.34 mL 1.72 mL 3.45 mL
10 mM 0.17 mL 0.86 mL 1.72 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Cersosimo et al (1986) Epirubicin: a review of pharmacology, clinical activity, and adverse effects of an adriamycin analogue. J.Clin.Oncol. 4 425 PMID: 3005521

Spadari et al (1986) DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs. Anticancer Res. 6 935 PMID: 3026237

Schott and Robert (1989) Comparative activity of anthracycline 13-dihydrometabolites against rat glioblastoma cells in culture. Biochem.Pharmacol. 38 4069 PMID: 2597184


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View all DNA, RNA and Protein Synthesis Inhibitors

Keywords: Epirubicin hydrochloride, Epirubicin hydrochloride supplier, inhibitors, inhibits, DNA, synthesis, function, topoisomerase, II, Isomerases, antibiotics, 4-Epidoxorubicin, chemotherapeutics, 4'-Epidoxorubicin, DNA,, RNA, and, Protein, Synthesis, Topoisomerase, Antibiotics, 3260, Tocris Bioscience

2 Citations for Epirubicin hydrochloride

Citations are publications that use Tocris products. Selected citations for Epirubicin hydrochloride include:

Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641 PMID: 24265703

Kim and Bynoe (2016) A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier. J Clin Invest 126 1717 PMID: 27043281


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Reviews for Epirubicin hydrochloride

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Epirubicin effectively kills melanoma cells in vitro.
By Anonymous on 02/14/2019
Assay Type: In Vitro
Species: Human

Epirubicin was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.

review image

Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis