Discontinued Product

Enterostatin (Cat. No. 3612) has been withdrawn from sale for commercial reasons.
Cat.No. 3612 - Enterostatin | Ala-Pro-Gly-Pro-Arg | CAS No. 117830-79-2
Description: Binds to β-subunit of F1-ATPase; anorexigenic peptide
Literature (1)

Biological Activity

N' terminal peptide fragment of procolipase that binds to the β-subunit of F1-ATPase. Activates the ERK and cAMP signaling pathways, and downregulates expression of Krüppel-like factor 4 (KLF4) and agouti-related peptide (AgRP) in vitro. Inhibits insulin secretion from pancreatic β-cells by downregulating expression of dynamin2 and altering protein trafficking. Reduces dietary fat intake via activation of CCK1, induces satiety, enhances memory-consolidation and exhibits hypocholesterolemic activity in vivo. Orally active.

Technical Data

M. Wt 496.57
Formula C21H36N8O6
Sequence APGPR
Storage Store at -20°C
CAS Number 117830-79-2
Smiles [H]N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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References are publications that support the biological activity of the product.

Takenaka et al (2008) Enterostatin reduces serum cholesterol levels by way of a CCK(1) receptor-dependent mechanism. Peptides 29 2175 PMID: 18824202

Park et al (2009) Enterostatin affects cyclic AMP and ERK signaling pathways to regulate Agouti-related Protein (AgRP) expression. Peptides 30 181 PMID: 19059445

Park et al (2009) Enterostatin alters protein trafficking to inhibit Ins secretion in Beta-TC6 cells. Peptides 30 1866 PMID: 19563849

Keywords: Enterostatin, Enterostatin supplier, Binds, β-subunit, beta-subunit, F1-ATPase, anorexigenic, peptide, activators, CCK1, reduces, dietary, fat, intake, P-Type, ATPase, V-Type, E-Type, F-Type, ATPases, GTPases, Oxidative, phosphorylation, Cholecystokinin1, Receptors, CCK, Cholecystokinin, H+-ATPase, Receptor, Phosphorylation, 3612, Tocris Bioscience

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