Enterostatin

Discontinued Product

Unfortunately Enterostatin (Cat. No. 3612) has been withdrawn from sale for commercial reasons.
Cat.No. 3612 - Enterostatin | Ala-Pro-Gly-Pro-Arg | CAS No. 117830-79-2
Description: Binds to β-subunit of F1-ATPase; anorexigenic peptide
Datasheet
Citations
Literature

Biological Activity

N' terminal peptide fragment of procolipase that binds to the β-subunit of F1-ATPase. Activates the ERK and cAMP signaling pathways, and downregulates expression of Krüppel-like factor 4 (KLF4) and agouti-related peptide (AgRP) in vitro. Inhibits insulin secretion from pancreatic β-cells by downregulating expression of dynamin2 and altering protein trafficking. Reduces dietary fat intake via activation of CCK1, induces satiety, enhances memory-consolidation and exhibits hypocholesterolemic activity in vivo. Orally active.

Technical Data

M. Wt 496.57
Formula C21H36N8O6
Sequence APGPR
Storage Store at -20°C
CAS Number 117830-79-2
Smiles [H]N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 496.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.07 mL 20.14 mL
5 mM 0.4 mL 2.01 mL 4.03 mL
10 mM 0.2 mL 1.01 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Takenaka et al (2008) Enterostatin reduces serum cholesterol levels by way of a CCK(1) receptor-dependent mechanism. Peptides 29 2175 PMID: 18824202

Park et al (2009) Enterostatin affects cyclic AMP and ERK signaling pathways to regulate Agouti-related Protein (AgRP) expression. Peptides 30 181 PMID: 19059445

Park et al (2009) Enterostatin alters protein trafficking to inhibit insulin secretion in Beta-TC6 cells. Peptides 30 1866 PMID: 19563849

Keywords: Enterostatin, supplier, Binds, β-subunit, beta-subunit, F1-ATPase, anorexigenic, peptide, activators, CCK1, reduces, dietary, fat, intake, P-Type, ATPase, V-Type, E-Type, F-Type, ATPases, GTPases, Oxidative, phosphorylation, Cholecystokinin1, Receptors, CCK, Cholecystokinin, H+-ATPase, CCK1, Receptor, Oxidative, Phosphorylation, H+-ATPase, Tocris Bioscience

Citations for Enterostatin

Citations are publications that use Tocris products.

Currently there are no citations for Enterostatin.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Enterostatin

Protocols

TODO: Add Protocols