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Biological Activity for Endomorphin-1
Endomorphin-1 is a endogenous peptide with an exceptionally high affinity (Ki = 360 pM) and selectivity for μ opioid receptors (4000- and 15000-fold preference over δ and κ respectively).
Technical Data for Endomorphin-1
(Modification: Phe-4 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Endomorphin-1
|Solubility||Soluble to 0.60 mg/ml in water|
References for Endomorphin-1
References are publications that support the biological activity of the product.
Goldberg et al (1998) Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 286 1007 PMID: 9694962
Harrison et al (1998) Differential effects of endomorphin-1, endomorphin-2, and tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes. Peptides 19 749 PMID: 9622031
Kakizawa et al (1998) Parallel stimulations of in vitro and in situ [35S]GTPγS binding by endomorphin 1 and DAMGO in mouse brains. Peptides 19 755 PMID: 9622032
Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499 PMID: 9087409
If you know of a relevant reference for Endomorphin-1, please let us know.
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Keywords: Endomorphin-1, Endomorphin-1 supplier, Potent, selective, μ-opioid, mu-opioid, agonists, MOP, Receptors, OP3, Mu, Opioid, 1055, Tocris Bioscience
3 Citations for Endomorphin-1
Citations are publications that use Tocris products. Selected citations for Endomorphin-1 include:
Hauser et al (2018) Pharmacogenomics of GPCR Drug Targets. Cell 172 41 PMID: 29249361
Garzón et al (2004) RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance. Neuropsychopharmacology 29 1091 PMID: 14997173
Dortch-Carnes and Russell (2007) Morphine-stimulated nitric oxide release in rabbit aqueous humor. Am J Physiol Endocrinol Metab 84 185 PMID: 17094965
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.