Endomorphin-1

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Cat.No. 1055 - Endomorphin-1 | Tyr-Pro-Trp-Phe-NH2 | CAS No. 189388-22-5
Description: Potent and selective μ agonist
Datasheet
Citations (2)
Literature

Biological Activity

Endogenous peptide with an exceptionally high affinity (Ki = 360 pM) and selectivity for μ opioid receptors (4000- and 15000-fold preference over δ and κ respectively).

Technical Data

M. Wt 610.67
Formula C34H38N6O5
Sequence YPWF

(Modifications: Phe-3 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 189388-22-5
PubChem ID 5311080
InChI Key ZEXLJFNSKAHNFH-SYKYGTKKSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.60 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 610.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.19 mL 16.38 mL
5 mM 0.33 mL 1.64 mL 3.28 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Goldberg et al (1998) Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 286 1007 PMID: 9694962

Harrison et al (1998) Differential effects of endomorphin-1, endomorphin-2, and tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes. Peptides 19 749 PMID: 9622031

Kakizawa et al (1998) Parallel stimulations of in vitro and in situ [35S]GTPγS binding by endomorphin 1 and DAMGO in mouse brains. Peptides 19 755 PMID: 9622032

Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499 PMID: 9087409


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Keywords: Endomorphin-1, supplier, Potent, selective, μ-opioid, mu-opioid, agonists, MOP, Receptors, OP3, Mu, Opioid, Receptors, Tocris Bioscience

2 Citations for Endomorphin-1

Citations are publications that use Tocris products. Selected citations for Endomorphin-1 include:

Dortch-Carnes and Russell (2007) Morphine-stimulated nitric oxide release in rabbit aqueous humor. Am J Physiol Endocrinol Metab 84 185 PMID: 17094965

Garzón et al (2004) RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance. Neuropsychopharmacology 29 1091 PMID: 14997173


Do you know of a great paper that uses Endomorphin-1 from Tocris? If so please let us know.

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Pathways for Endomorphin-1

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