EIDD 1931

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Description: Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleoside
Chemical Name: N-Hydroxycytidine
Purity: ≥98% (HPLC)

Biological Activity for EIDD 1931

EIDD 1931 is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide. Inhibits replication of a range of RNA viruses including influenza, Ebola, HCV, and human and zoonotic coronaviruses (IC50 values are 0.15 and 0.3 μM for inhibition of MERS-CoV and SARS-CoV-2 replication in vitro). Increases mutation rates and induces lethal mutagenesis in viral RNA. Also inhibits replication of mouse hepatitis virus with mutations conferring resistance to remdesivir (Cat. No. 7226).

Compound Libraries for EIDD 1931

EIDD 1931 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for EIDD 1931

M. Wt 259.22
Formula C9H13N3O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 3258-02-4
PubChem ID 197020
Smiles OC[C@H]1O[C@@H](N2C=C/C(NC2=O)=N\O)[C@@H]([C@@H]1O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for EIDD 1931

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.92 100
water 12.96 50

Preparing Stock Solutions for EIDD 1931

The following data is based on the product molecular weight 259.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.86 mL 19.29 mL 38.58 mL
5 mM 0.77 mL 3.86 mL 7.72 mL
10 mM 0.39 mL 1.93 mL 3.86 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

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References for EIDD 1931

References are publications that support the biological activity of the product.

Urakova et al (2018) β-d-N4-hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome. J.Virol. 92 PMID: 29167335

Sheahan et al (2020) An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci.Transl.Med. 12 PMID: 32253226

If you know of a relevant reference for EIDD 1931, please let us know.

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Citations for EIDD 1931

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