EIDD 1931

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Cat.No. 7231 - EIDD 1931 | C9H13N3O6 | CAS No. 3258-02-4
Description: Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide
Chemical Name: N-Hydroxycytidine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide. Inhibits replication of a range of RNA viruses including influenza, Ebola, HCV, and human and zoonotic coronaviruses (IC50 values are 0.15 and 0.3 μM for inhibition of MERS-CoV and SARS-CoV-2 replication in vitro). Increases mutation rates and induces lethal mutagenesis in viral RNA. Also inhibits replication of mouse hepatitis virus with mutations conferring resistance to remdesivir (Cat. No. 7226).

Technical Data

M. Wt 259.22
Formula C9H13N3O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 3258-02-4
PubChem ID 197020
InChI Key XCUAIINAJCDIPM-XVFCMESISA-N
Smiles OC[C@H]1O[C@@H](N2C=C/C(NC2=O)=N\O)[C@@H]([C@@H]1O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.92 100
water 12.96 50

Preparing Stock Solutions

The following data is based on the product molecular weight 259.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.86 mL 19.29 mL 38.58 mL
5 mM 0.77 mL 3.86 mL 7.72 mL
10 mM 0.39 mL 1.93 mL 3.86 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

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References

References are publications that support the biological activity of the product.

Urakova et al (2018) β-d-N4-hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome. J.Virol. 92 PMID: 29167335

Sheahan et al (2020) An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci.Transl.Med. 12 PMID: 32253226


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