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Biological Activity for Edelfosine
Edelfosine is a synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50= 9.6 μM in fibroblasts and adenocarcinoma cells). Also acts as an agonist at platelet-activating factor (PAF) receptors. Antitumor lipid; selectively induces apoptosis in tumor cells, sparing normal cells.
Technical Data for Edelfosine
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Edelfosine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||2.62||5 with gentle warming|
Preparing Stock Solutions for Edelfosine
The following data is based on the product molecular weight 523.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||38.19 mL||190.94 mL||381.88 mL|
|0.25 mM||7.64 mL||38.19 mL||76.38 mL|
|0.5 mM||3.82 mL||19.09 mL||38.19 mL|
|2.5 mM||0.76 mL||3.82 mL||7.64 mL|
References for Edelfosine
References are publications that support the biological activity of the product.
Powis et al (1992) Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res. 52 2835 PMID: 1316230
Aoki et al (1995) A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J.Immunol.Methods 186 225 PMID: 7594622
Shimizu et al (2007) Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats. Eur.J.Pharmacol. 571 138 PMID: 17628524
Wong et al (2007) Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis. BMC Cell Biol. 8 15 PMID: 17509155
If you know of a relevant reference for Edelfosine, please let us know.
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Keywords: Edelfosine, Edelfosine supplier, Selective, PI-PLC, inhibitors, inhibits, PAF, receptor, Phospholipases, C, Phosphoinositide-Specific, Esterases, Platelet-activating, Factor, Receptors, ET18OCH3, ET-18-OCH3, (PAF), Phospholipase, 3022, Tocris Bioscience
9 Citations for Edelfosine
Citations are publications that use Tocris products. Selected citations for Edelfosine include:
Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333
Melchior and Frangos (2012) Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells. Cancer Biol Ther 303 C467 PMID: 22700794
Korb et al (2013) Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity. Nat Neurosci 16 874 PMID: 23749147
Pitt et al (2017) Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers. Mol Biol Cell 28 2623 PMID: 28963439
Liu et al (2015) A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci Signal 8 ra71 PMID: 26198357
Yu et al (2017) PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development. Nat Commun 8 1457 PMID: 29133930
Ailte et al (2017) Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis. Traffic 18 176 PMID: 28067430
Ozkucur et al (2014) NHE3 phosphorylation via PKCη marks the polarity and orientation of directionally migrating cells. Cell Mol Life Sci 71 4653 PMID: 24788043
Zhao (2014) BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol 111 1008 PMID: 24335212
Do you know of a great paper that uses Edelfosine from Tocris? Please let us know.
Reviews for Edelfosine
Average Rating: 4 (Based on 1 Review.)
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Literature in this Area
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