Edelfosine

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Cat.No. 3022 - Edelfosine | C27H58NO6P | CAS No. 77286-66-9
Description: Selective PI-PLC inhibitor, also PAF receptor agonist
Alternative Names: ET-18-OCH3
Chemical Name: (7R)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium-4-oxide
Datasheet
Citations (9)
Reviews (1)
Literature (3)

Biological Activity

Synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50= 9.6 μM in fibroblasts and adenocarcinoma cells). Also acts as an agonist at platelet-activating factor (PAF) receptors. Antitumor lipid; selectively induces apoptosis in tumor cells, sparing normal cells.

Technical Data

M. Wt 523.73
Formula C27H58NO6P
Storage Store at -20°C
CAS Number 77286-66-9
PubChem ID 6918215
InChI Key MHFRGQHAERHWKZ-HHHXNRCGSA-N
Smiles CO[C@@H](COP(OCC[N+](C)(C)C)([O-])=O)COCCCCCCCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.62 5 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 523.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 38.19 mL 190.94 mL 381.88 mL
0.25 mM 7.64 mL 38.19 mL 76.38 mL
0.5 mM 3.82 mL 19.09 mL 38.19 mL
2.5 mM 0.76 mL 3.82 mL 7.64 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Powis et al (1992) Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res. 52 2835 PMID: 1316230

Aoki et al (1995) A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J.Immunol.Methods 186 225 PMID: 7594622

Shimizu et al (2007) Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats. Eur.J.Pharmacol. 571 138 PMID: 17628524

Wong et al (2007) Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis. BMC Cell Biol. 8 15 PMID: 17509155


If you know of a relevant reference for Edelfosine, please let us know.

View Related Products by Product Action

View all Phospholipase Inhibitors

Keywords: Edelfosine, Edelfosine supplier, Selective, PI-PLC, inhibitors, inhibits, PAF, receptor, Phospholipases, C, Phosphoinositide-Specific, Esterases, Platelet-activating, Factor, Receptors, ET18OCH3, ET-18-OCH3, (PAF), Phospholipase, 3022, Tocris Bioscience

9 Citations for Edelfosine

Citations are publications that use Tocris products. Selected citations for Edelfosine include:

Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333

Korb et al (2013) Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity. Nat Neurosci 16 874 PMID: 23749147

Melchior and Frangos (2012) Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells. Cancer Biol Ther 303 C467 PMID: 22700794

Yu et al (2017) PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development. Nat Commun 8 1457 PMID: 29133930


Do you know of a great paper that uses Edelfosine from Tocris? Please let us know.

Reviews for Edelfosine

Average Rating: 4 (Based on 1 Review.)

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works well.
By Anonymous on 03/26/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Hippocampal neuron

10uM

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