EC 19

Pricing Availability   Qty
Cat.No. 5849 - EC 19 | C23H24O2 | CAS No. 1010694-08-2
Description: Synthetic retinoid; induces differentiation of stem cells
Chemical Name: 3-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Synthetic analogue of all trans-retinoic acid. Promotes differentiation of human embryonal carcinoma (EC) cells primarily into epithelial-like cells, along with a small number of neurons.

Technical Data

M. Wt 332.44
Formula C23H24O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1010694-08-2
PubChem ID 25111943
InChI Key PMRFEKRJNZQOSY-UHFFFAOYSA-N
Smiles CC1(C)C2=C(C=CC(C#CC3=CC(C(O)=O)=CC=C3)=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.62 50

Preparing Stock Solutions

The following data is based on the product molecular weight 332.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.02 mL 30.08 mL 60.16 mL
2.5 mM 1.2 mL 6.02 mL 12.03 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
25 mM 0.12 mL 0.6 mL 1.2 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Christie et al (2008) Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Org.Biomol.Chem. 6 3497 PMID: 19082150

Clemens et al (2013) The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy. Mol.Biosyst. 9 677 PMID: 23364809


If you know of a relevant reference for EC 19, please let us know.

Keywords: EC 19, EC 19 supplier, EC19, synthetic, all-trans, retinoic, acid, receptors, ATRA, differentiation, stem, cells, retinoids, Retinoic, Acid, Receptors, Retinal, Stem, Cells, 5849, Tocris Bioscience

Citations for EC 19

Citations are publications that use Tocris products.

Currently there are no citations for EC 19. Do you know of a great paper that uses EC 19 from Tocris? Please let us know.

Reviews for EC 19

There are currently no reviews for this product. Be the first to review EC 19 and earn rewards!

Have you used EC 19?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors
Retinoid Receptors

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.