EC 19

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Cat.No. 5849 - EC 19 | C23H24O2 | CAS No. 1010694-08-2
Description: Synthetic retinoid; induces differentiation of stem cells
Chemical Name: 3-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl]benzoic acid
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity

Synthetic analogue of all trans-retinoic acid. Promotes differentiation of human embryonal carcinoma (EC) cells primarily into epithelial-like cells, along with a small number of neurons.

Technical Data

M. Wt 332.44
Formula C23H24O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1010694-08-2
PubChem ID 25111943
Smiles CC1(C)C2=C(C=CC(C#CC3=CC(C(O)=O)=CC=C3)=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 16.62 50

Preparing Stock Solutions

The following data is based on the product molecular weight 332.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.02 mL 30.08 mL 60.16 mL
2.5 mM 1.2 mL 6.02 mL 12.03 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
25 mM 0.12 mL 0.6 mL 1.2 mL

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References are publications that support the biological activity of the product.

Christie et al (2008) Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Org.Biomol.Chem. 6 3497 PMID: 19082150

Clemens et al (2013) The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy. Mol.Biosyst. 9 677 PMID: 23364809

If you know of a relevant reference for EC 19, please let us know.

Keywords: EC 19, EC 19 supplier, EC19, synthetic, all-trans, retinoic, acid, receptors, ATRA, differentiation, stem, cells, retinoids, Retinoic, Acid, Receptors, Retinal, Stem, Cells, 5849, Tocris Bioscience

Citations for EC 19

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