Ebselen

Pricing Availability Delivery Time Qty
Cat.No. 5245 - Ebselen | C13H9NOSe | CAS No. 60940-34-3
Description: Glutathione peroxidase mimic; peroxynitrite scavenger
Chemical Name: 2-Phenyl-1,2-benzisoselenazol-3(2H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Glutathione peroxidase mimic; peroxynitrite scavenger. Inhibits lipoxygenase, cyclooxygenase, nitric oxide synthase, protein kinase C and H+/K+-ATPase activity. Inhibits the hepatic carcinogenic effects of aflatoxin B1. Antioxidant and anti-inflammatory.

Technical Data

M. Wt 274.18
Formula C13H9NOSe
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 60940-34-3
PubChem ID 3194
InChI Key DYEFUKCXAQOFHX-UHFFFAOYSA-N
Smiles O=C2C1=CC=CC=C1[Se]N2C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.42 100
ethanol 2.74 10

Preparing Stock Solutions

The following data is based on the product molecular weight 274.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.65 mL 18.24 mL 36.47 mL
5 mM 0.73 mL 3.65 mL 7.29 mL
10 mM 0.36 mL 1.82 mL 3.65 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Schewe (1995) Molecular actions of ebselen--an antiinflammatory antioxidant. Gen.Pharmacol. 26 1153 PMID: 7590103

Yang et al (2000) Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats. Carcinogenesis 21 2237 PMID: 11133813

Fujisawa and Kadoma (2005) Kinetic studies of the radical-scavenging activity of ebselen, a seleno-organic compound. Anticancer Res. 25 3989 PMID: 16309189


If you know of a relevant reference for Ebselen, please let us know.

View Related Products by Target

Keywords: Ebselen, supplier, Glutathione, peroxidase, mimic, peroxynitrite, scavenger, inhibts, inhibitors, inhibits, lipoxygenases, cyclooxygenases, nitric, oxide, synthases, protein, kinase, C, H+, K+, atpases, Antioxidant, anti-inflammatory, Antioxidants, Antioxidants, Tocris Bioscience

Citations for Ebselen

Citations are publications that use Tocris products.

Currently there are no citations for Ebselen. Do you know of a great paper that uses Ebselen from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Ebselen

Protocols

TODO: Add Protocols