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Cat.No. 5245 - Ebselen | C13H9NOSe | CAS No. 60940-34-3
Description: Glutathione peroxidase mimic; peroxynitrite scavenger
Chemical Name: 2-Phenyl-1,2-benzisoselenazol-3(2H)-one
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity

Glutathione peroxidase mimic; peroxynitrite scavenger. Inhibits ferroptosis. Also inhibits lipoxygenase, cyclooxygenase, nitric oxide synthase, protein kinase C and H+/K+-ATPase activity. Inhibits the hepatic carcinogenic effects of aflatoxin B1. Antioxidant and anti-inflammatory. Selectively inhibits Gq protein signaling and enhances differentiation of brown adipocytes. Inhibits SARS-CoV-2 Mpro in vitro (IC50 = 0.67 μM in FRET assay)

Technical Data

M. Wt 274.18
Formula C13H9NOSe
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 60940-34-3
PubChem ID 3194
Smiles O=C2C1=CC=CC=C1[Se]N2C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 274.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.65 mL 18.24 mL 36.47 mL
5 mM 0.73 mL 3.65 mL 7.29 mL
10 mM 0.36 mL 1.82 mL 3.65 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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References are publications that support the biological activity of the product.

Schewe (1995) Molecular actions of ebselen--an antiinflammatory antioxidant. Gen.Pharmacol. 26 1153 PMID: 7590103

Yang et al (2000) Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats. Carcinogenesis 21 2237 PMID: 11133813

Fujisawa and Kadoma (2005) Kinetic studies of the radical-scavenging activity of ebselen, a seleno-organic compound. Anticancer Res. 25 3989 PMID: 16309189

Kuschak et al (2019) Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics, and identify small molecule inhibitors. Br.J.Pharmacol. 177 1898 PMID: 31881095

Xie et al (2016) Ferroptosis: process and function. Cell Death Differ. 23 369 PMID: 26794443

Jin et al (2020) Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 582 289 PMID: 32272481

If you know of a relevant reference for Ebselen, please let us know.

Keywords: Ebselen, Ebselen supplier, Glutathione, peroxidase, mimic, peroxynitrite, scavenger, inhibts, inhibitors, inhibits, lipoxygenases, cyclooxygenases, nitric, oxide, synthases, protein, kinase, C, H+, K+, atpases, Antioxidant, anti-inflammatory, ferroptosis, Gq, proteins, signaling, adipoc, Antioxidants, Ferroptosis, Heterotrimeric, G-protein, GTPases, COVID-19, 3C, and, 3CL, Proteases, 5245, Tocris Bioscience

1 Citation for Ebselen

Citations are publications that use Tocris products. Selected citations for Ebselen include:

Kuschak et al (2019) Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics, and identify small molecule inhibitors. Br.J.Pharmacol. 177 1898 PMID: 31881095

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Literature in this Area

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