Ebselen

Pricing Availability   Qty
Cat.No. 5245 - Ebselen | C13H9NOSe | CAS No. 60940-34-3
Description: Glutathione peroxidase mimic; peroxynitrite scavenger
Chemical Name: 2-Phenyl-1,2-benzisoselenazol-3(2H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity

Glutathione peroxidase mimic; peroxynitrite scavenger. Inhibits ferroptosis. Also inhibits lipoxygenase, cyclooxygenase, nitric oxide synthase, protein kinase C and H+/K+-ATPase activity. Inhibits the hepatic carcinogenic effects of aflatoxin B1. Antioxidant and anti-inflammatory. Selectively inhibits Gq protein signaling and enhances differentiation of brown adipocytes. Inhibits SARS-CoV-2 Mpro in vitro (IC50 = 0.67 μM in FRET assay)

Technical Data

M. Wt 274.18
Formula C13H9NOSe
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 60940-34-3
PubChem ID 3194
InChI Key DYEFUKCXAQOFHX-UHFFFAOYSA-N
Smiles O=C2C1=CC=CC=C1[Se]N2C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 274.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.65 mL 18.24 mL 36.47 mL
5 mM 0.73 mL 3.65 mL 7.29 mL
10 mM 0.36 mL 1.82 mL 3.65 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Schewe (1995) Molecular actions of ebselen--an antiinflammatory antioxidant. Gen.Pharmacol. 26 1153 PMID: 7590103

Yang et al (2000) Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats. Carcinogenesis 21 2237 PMID: 11133813

Fujisawa and Kadoma (2005) Kinetic studies of the radical-scavenging activity of ebselen, a seleno-organic compound. Anticancer Res. 25 3989 PMID: 16309189

Kuschak et al (2019) Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics, and identify small molecule inhibitors. Br.J.Pharmacol. 177 1898 PMID: 31881095

Xie et al (2016) Ferroptosis: process and function. Cell Death Differ. 23 369 PMID: 26794443

Jin et al (2020) Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 582 289 PMID: 32272481


If you know of a relevant reference for Ebselen, please let us know.

Keywords: Ebselen, Ebselen supplier, Glutathione, peroxidase, mimic, peroxynitrite, scavenger, inhibts, inhibitors, inhibits, lipoxygenases, cyclooxygenases, nitric, oxide, synthases, protein, kinase, C, H+, K+, atpases, Antioxidant, anti-inflammatory, ferroptosis, Gq, proteins, signaling, adipoc, Antioxidants, Ferroptosis, Heterotrimeric, G-protein, GTPases, COVID-19, 3C, and, 3CL, Proteases, 5245, Tocris Bioscience

1 Citation for Ebselen

Citations are publications that use Tocris products. Selected citations for Ebselen include:

Kuschak et al (2019) Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics, and identify small molecule inhibitors. Br.J.Pharmacol. 177 1898 PMID: 31881095


Do you know of a great paper that uses Ebselen from Tocris? Please let us know.

Reviews for Ebselen

There are currently no reviews for this product. Be the first to review Ebselen and earn rewards!

Have you used Ebselen?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells