DMAT

Discontinued Product

DMAT (Cat. No. 3686) has been withdrawn from sale for commercial reasons.
Cat.No. 3686 - DMAT | C9H7Br4N3
Description: Cell-permeable inhibitor of CK2; also inhibits Pim kinase and PKD1
Chemical Name: 2-(Dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidazole
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity, cell-permeable inhibitor of casein kinase 2 (CK2) (Ki = 40 nM; IC50 = 0.13 μM). Displays no activity at CK1 at concentrations up to 200 μM. Also inhibits Pim kinase (IC50 values are 0.097, 0.148 and 1.6 μM for Pim-3, Pim-1 and Pim-2 kinase respectively), and protein kinase D1 (IC50 = 0.18 μM). Derivative of TBB (Cat.No. 2275).

Technical Data

M. Wt 476.79
Formula C9H7Br4N3
Storage Store at +4°C
Purity ≥99% (HPLC)
Smiles BrC1=C(Br)C(Br)=C(NC(N(C)C)=N2)C2=C1Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

References

References are publications that support the biological activity of the product.

Inglis et al (2008) Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J.Biol.Chem. 284 2598 PMID: 19004816

Pagano et al (2008) The selectivity of inhibitors of protein kinase CK2: an update. Biochem.J. 415 353 PMID: 18588507

Pagano et al (2004) 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2. Biochem.Biophys.Res.Comm. 321 1040

View Related Products by Product Action

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Keywords: DMAT, DMAT supplier, cell-permeable, kinase, inhibitors, inhibits, casein, 2, CK2, pim, pim1, pim2, pim3, protein, d1, pkd1, Casein, Kinase, Pim, Protein, D, 3686, Tocris Bioscience

Citations for DMAT

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Currently there are no citations for DMAT.

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Literature in this Area

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