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High affinity, cell-permeable inhibitor of casein kinase 2 (CK2) (Ki = 40 nM; IC50 = 0.13 μM). Displays no activity at CK1 at concentrations up to 200 μM. Also inhibits Pim kinase (IC50 values are 0.097, 0.148 and 1.6 μM for Pim-3, Pim-1 and Pim-2 kinase respectively), and protein kinase D1 (IC50 = 0.18 μM). Derivative of TBB (Cat.No. 2275).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Inglis et al (2008) Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J.Biol.Chem. 284 2598 PMID: 19004816
Pagano et al (2008) The selectivity of inhibitors of protein kinase CK2: an update. Biochem.J. 415 353 PMID: 18588507
Pagano et al (2004) 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2. Biochem.Biophys.Res.Comm. 321 1040
Keywords: DMAT, DMAT supplier, cell-permeable, kinase, inhibitors, inhibits, casein, 2, CK2, pim, pim1, pim2, pim3, protein, d1, pkd1, Casein, Kinase, Pim, Protein, D, 3686, Tocris Bioscience
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