(±)-Eriodictyol

Pricing Availability   Qty
Cat.No. 7199 - (±)-Eriodictyol | C15H12O6 | CAS No. 4049-38-1
Description: Potent TRPV1 antagonist; also antioxidant; activates Nrf2/ARE signaling
Chemical Name: 2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Potent TRPV1 antagonist. Inhibits capsaicin (Cat. No. 0462) -induced Ca2+ influx in synaptosomes. Exhibits antinociceptive activity in animal models without affecting body temperature. Also antioxidant; protects against H2O2-induced neurotoxicity in vitro by activation of Nrf2/ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with SARS-CoV-2 S protein. Naturally-derived flavonoid. Orally bioavailable.

Technical Data

M. Wt 288.26
Formula C15H12O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 4049-38-1
PubChem ID 11095
InChI Key SBHXYTNGIZCORC-UHFFFAOYSA-N
Smiles OC1=CC(O)=C2C(CC(C3=CC(O)=C(C=C3)O)OC2=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.83 100
ethanol 14.41 50

Preparing Stock Solutions

The following data is based on the product molecular weight 288.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.47 mL 17.35 mL 34.69 mL
5 mM 0.69 mL 3.47 mL 6.94 mL
10 mM 0.35 mL 1.73 mL 3.47 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Smith and Smith et al (2020) Repurposing therapeutics for COVID-19: Supercomputer-based docking to the SARS-CoV-2 viral spike protein and viral spike protein-human ACE2 interface. ChemRxiv - Paper not yet peer reviewed

Rossato et al (2011) Eriodictyol: A flavonoid antagonist of the TRPV1 receptor with antioxidant activity. Biochem.Pharmacol. 81 544 PMID: 21087598

Lou et al (2012) Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway. Neurochem.Int. 61 251 PMID: 22609376


If you know of a relevant reference for (±)-Eriodictyol, please let us know.

View Related Products by Product Action

View all TRPV Antagonists

Keywords: (±)-Eriodictyol, (±)-Eriodictyol supplier, Transient, receptor, potential, vanilloid, 1, TRPV1, potent, antagonist, antagonists, antagonism, antioxidant, ACE2, ligand, SARS-CoV-2, COVID-19, Nrf2, signaling, activators, activator, activates, TRPV, 7199, Tocris Bioscience

Citations for (±)-Eriodictyol

Citations are publications that use Tocris products.

Currently there are no citations for (±)-Eriodictyol. Do you know of a great paper that uses (±)-Eriodictyol from Tocris? Please let us know.

Reviews for (±)-Eriodictyol

There are currently no reviews for this product. Be the first to review (±)-Eriodictyol and earn rewards!

Have you used (±)-Eriodictyol?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Pain

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.