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Potent TRPV1 antagonist. Inhibits capsaicin (Cat. No. 0462) -induced Ca2+ influx in synaptosomes. Exhibits antinociceptive activity in animal models without affecting body temperature. Also antioxidant; protects against H2O2-induced neurotoxicity in vitro by activation of Nrf2/ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with SARS-CoV-2 S protein. Naturally-derived flavonoid. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 288.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.47 mL||17.35 mL||34.69 mL|
|5 mM||0.69 mL||3.47 mL||6.94 mL|
|10 mM||0.35 mL||1.73 mL||3.47 mL|
|50 mM||0.07 mL||0.35 mL||0.69 mL|
References are publications that support the biological activity of the product.
Smith and Smith et al (2020) Repurposing therapeutics for COVID-19: Supercomputer-based docking to the SARS-CoV-2 viral spike protein and viral spike protein-human ACE2 interface. ChemRxiv - Paper not yet peer reviewed
Rossato et al (2011) Eriodictyol: A flavonoid antagonist of the TRPV1 receptor with antioxidant activity. Biochem.Pharmacol. 81 544 PMID: 21087598
Lou et al (2012) Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway. Neurochem.Int. 61 251 PMID: 22609376
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.