Pricing Availability   Qty
Description: Maintains SH groups in the reduced state
Alternative Names: DTT,Cleland's reagent,Sputolysin
Chemical Name: threo-1,4-Dimercapto-2,3-butanediol
Purity: ≥98%
Citations (1)

Biological Activity for DL-Dithiothreitol

DL-Dithiothreitol is a reagent for maintaining SH groups in the reduced state.

Technical Data for DL-Dithiothreitol

M. Wt 154.25
Formula C4H10O2S2
Storage Store at +4°C
Purity ≥98%
CAS Number 3483-12-3
PubChem ID 51341375
Smiles SC[C@H](O)[C@@H](O)CS.SC[C@@H](O)[C@H](O)CS

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DL-Dithiothreitol

Solvent Max Conc. mg/mL Max Conc. mM
water 15.42 100

Preparing Stock Solutions for DL-Dithiothreitol

The following data is based on the product molecular weight 154.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.48 mL 32.41 mL 64.83 mL
5 mM 1.3 mL 6.48 mL 12.97 mL
10 mM 0.65 mL 3.24 mL 6.48 mL
50 mM 0.13 mL 0.65 mL 1.3 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for DL-Dithiothreitol

Certificate of Analysis / Product Datasheet
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References for DL-Dithiothreitol

References are publications that support the biological activity of the product.

Rüegg and Rudinger (1977) Reductive cleavage of cystine disulfides with tributylphosphine. Methods Enzymol. 47 111 PMID: 927167

Sears et al (1977) Relative susceptibilities of the interchain disulfides of an immunoglobulin G molecule to reduction by dithiothreitol. Biochemistry 16 2031 PMID: 403938

Jabusch et al (1978) The effect of thiodiglycol and dithiothreitol on the alkaline hydrolysis products of certain amino acid phenylthiohydantoins. Anal.Biochem. 91 532 PMID: 9762140

Cleland (1964) Dithiothreitol, a new protective group for SH groups. Biochemistry 3 480 PMID: 14192894

If you know of a relevant reference for DL-Dithiothreitol, please let us know.

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Keywords: DL-Dithiothreitol, DL-Dithiothreitol supplier, Maintains, SH, groups, reduced, state, Reagents, Clelands, reagent, DTT, Cleland's, Sputolysin, Biochemicals, and, Molecular, Biology, 3154, Tocris Bioscience

1 Citation for DL-Dithiothreitol

Citations are publications that use Tocris products. Selected citations for DL-Dithiothreitol include:

Baca et al (2013) Gene-environment interactions affect long-term depression (LTD) through changes in DA receptor affinity in Snap25 deficient mice. Brain Res 1532 85 PMID: 23939223

Do you know of a great paper that uses DL-Dithiothreitol from Tocris? Please let us know.

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