(±)-α-Lipoamide

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Cat.No. 7045 - (±)-a-Lipoamide | C8H15NOS2 | CAS No. 940-69-2
Description: Phase-separated condensate modifier; orally bioavailable
Chemical Name: 1,2-Dithiolane-3-pentanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Phase-separated condensate modifier. Reduces propensity of stress granule proteins to aggregate (EC50 = 20 μM in HeLa and iPSCs), and causes FUS stress granule proteins to return to the nucleus in vitro. Stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of ALS patient-derived (FUS mutant) motor neuron axons in culture, and recovers motor defects in D. melanogaster expressing FUS mutants. Suppresses the effects of ALS-associated FUS mutations in vivo in different systems. Orally bioavailable.

Technical Data

M. Wt 205.33
Formula C8H15NOS2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 940-69-2
PubChem ID 863
InChI Key FCCDDURTIIUXBY-UHFFFAOYSA-N
Smiles NC(CCCCC1CCSS1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.53 100
ethanol 4.11 20

Preparing Stock Solutions

The following data is based on the product molecular weight 205.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.87 mL 24.35 mL 48.7 mL
5 mM 0.97 mL 4.87 mL 9.74 mL
10 mM 0.49 mL 2.44 mL 4.87 mL
50 mM 0.1 mL 0.49 mL 0.97 mL

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References

References are publications that support the biological activity of the product.

Shen et al (2011) Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. Br.J.Pharmacol. 162 1213 PMID: 21108628

Wheeler et al (2019) Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease


If you know of a relevant reference for (±)-α-Lipoamide, please let us know.

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Citations for (±)-α-Lipoamide

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Literature in this Area

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