(±)-α-Lipoamide

Cat. No. 7045 Submit a Review Datasheet / COA / SDS

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Description: Phase-separated condensate modifier; orally bioavailable

Chemical Name: 1,2-Dithiolane-3-pentanamide

Purity: ≥98% (HPLC)

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Citations

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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for (±)-α-Lipoamide

(±)-α-Lipoamide is a phase-separated condensate modifier. Reduces propensity of stress granule proteins to aggregate (EC₅₀ = 20 μM in HeLa and iPSCs), and causes FUS stress granule proteins to return to the nucleus in vitro. Stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of ALS patient-derived (FUS mutant) motor neuron axons in culture, and recovers motor defects in D. melanogaster expressing FUS mutants. Suppresses the effects of ALS-associated FUS mutations in vivo in different systems. Orally bioavailable.

Technical Data for (±)-α-Lipoamide

M. Wt	205.33
Formula	C₈H₁₅NOS₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	940-69-2
PubChem ID	863
InChI Key	FCCDDURTIIUXBY-UHFFFAOYSA-N
Smiles	NC(CCCCC1CCSS1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (±)-α-Lipoamide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.53	100
	ethanol	4.11	20

Preparing Stock Solutions for (±)-α-Lipoamide

The following data is based on the product molecular weight 205.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.87 mL	24.35 mL	48.7 mL
5 mM	0.97 mL	4.87 mL	9.74 mL
10 mM	0.49 mL	2.44 mL	4.87 mL
50 mM	0.1 mL	0.49 mL	0.97 mL

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Product Datasheets for (±)-α-Lipoamide

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for (±)-α-Lipoamide

References are publications that support the biological activity of the product.

Shen et al (2011) Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. Br.J.Pharmacol. 162 1213 PMID: 21108628

Wheeler et al (2019) Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease

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Biochemicals and Molecular Biology

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Citations for (±)-α-Lipoamide

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