DIM

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Cat.No. 4502 - DIM | C17H14N2 | CAS No. 1968-05-4
Description: Inhibits EGFR activation; also induces apoptosis
Alternative Names: 3,3-Diindolylmethane
Chemical Name: 3,3'-Methylenediindole
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.

Technical Data

M. Wt 246.31
Formula C17H14N2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1968-05-4
PubChem ID 10900930
InChI Key SHXKYUYEFDONQC-UHFFFAOYSA-N
Smiles C12=CC=CC=C1C(CC3=CC(C=CC=C4)=C4N3)=CN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.63 100
ethanol 12.32 50

Preparing Stock Solutions

The following data is based on the product molecular weight 246.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.06 mL 20.3 mL 40.6 mL
5 mM 0.81 mL 4.06 mL 8.12 mL
10 mM 0.41 mL 2.03 mL 4.06 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kandala et al (2012) Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. J.Pharmacol.Exp.Ther. 341 24 PMID: 22205686

Kandala & Srivastava (2010) Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Mol.Pharmacol. 78 297 PMID: 20444961

Shorey et al (2012) 3,3'-diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One. 7 e34975 PMID: 22514694


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