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Biological Activity for DIM
DIM is an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.
Technical Data for DIM
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for DIM
References are publications that support the biological activity of the product.
Kandala et al (2012) Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. J.Pharmacol.Exp.Ther. 341 24 PMID: 22205686
Kandala & Srivastava (2010) Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Mol.Pharmacol. 78 297 PMID: 20444961
Shorey et al (2012) 3,3'-diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One. 7 e34975 PMID: 22514694
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Keywords: DIM, DIM supplier, Chk2, checkpoint, kinase, 2, activators, antiproliferatives, anticancer, chemotherapeutics, epidermal, growth, factor, receptors, EGFR, inhibitors, inhibits, pro-apoptotic, apoptosis, inducers, 3,3-diindolylmethane, 3,3-Diindolylmethane, Checkpoint, Control, Kinases, Cell, Cycle, Inhibitors, Other, Apoptosis, 4502, Tocris Bioscience
Citations for DIM
Citations are publications that use Tocris products.
Currently there are no citations for DIM.
Reviews for DIM
Average Rating: 5 (Based on 1 Review.)
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.