DIM
Biological Activity
Activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.
Technical Data
| M. Wt | 246.31 |
| Formula | C17H14N2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1968-05-4 |
| PubChem ID | 10900930 |
| InChI Key | SHXKYUYEFDONQC-UHFFFAOYSA-N |
| Smiles | C12=CC=CC=C1C(CC3=CC(C=CC=C4)=C4N3)=CN2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.63 | 100 | |
| ethanol | 12.32 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 246.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.06 mL | 20.3 mL | 40.6 mL |
| 5 mM | 0.81 mL | 4.06 mL | 8.12 mL |
| 10 mM | 0.41 mL | 2.03 mL | 4.06 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.81 mL |
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References
References are publications that support the biological activity of the product.
Kandala et al (2012) Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. J.Pharmacol.Exp.Ther. 341 24 PMID: 22205686
Kandala & Srivastava (2010) Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Mol.Pharmacol. 78 297 PMID: 20444961
Shorey et al (2012) 3,3'-diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One. 7 e34975 PMID: 22514694
If you know of a relevant reference for DIM, please let us know.
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Citations for DIM
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A collection of over 750 products for cancer research, the guide includes research tools for the study of:
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