Discontinued Product

DIM (Cat. No. 4502) has been withdrawn from sale for commercial reasons.
Description: Inhibits EGFR activation; also induces apoptosis
Alternative Names: 3,3-Diindolylmethane
Chemical Name: 3,3'-Methylenediindole
Purity: ≥99% (HPLC)
Reviews (1)
Literature (1)

Biological Activity for DIM

DIM is an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.

Technical Data for DIM

M. Wt 246.31
Formula C17H14N2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1968-05-4
PubChem ID 10900930
Smiles C12=CC=CC=C1C(CC3=CC(C=CC=C4)=C4N3)=CN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for DIM

References are publications that support the biological activity of the product.

Kandala et al (2012) Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. J.Pharmacol.Exp.Ther. 341 24 PMID: 22205686

Kandala & Srivastava (2010) Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Mol.Pharmacol. 78 297 PMID: 20444961

Shorey et al (2012) 3,3'-diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One. 7 e34975 PMID: 22514694

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Citations for DIM

Citations are publications that use Tocris products.

Currently there are no citations for DIM.

Reviews for DIM

Average Rating: 5 (Based on 1 Review.)

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Determination of DIM suppression of EGFR.
By Anonymous on 12/14/2019
Species: Human

To determine whether DIM suppressed the activation of EGFR by activating phosphorylation, cells were treated with epidermal growth factor.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.