Nur77 agonist. Induces apoptosis in cancer cell lines in vitro. Enhances long-term potentiation in hippocampal slices and long-term contextual fear memory in an in vivo mouse model.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 352.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.84 mL||14.19 mL||28.37 mL|
|5 mM||0.57 mL||2.84 mL||5.67 mL|
|10 mM||0.28 mL||1.42 mL||2.84 mL|
|50 mM||0.06 mL||0.28 mL||0.57 mL|
References are publications that support the products' biological activity.
Bridi et al (2017) Pharmacological activators of the NR4A nuclear receptors enhance LTP in a CREB/CBP-dependent manner. Neuropsychopharmacology 42 1243 PMID: 27834392
Chintharlapalli et al (2005) Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J.Biol.Chem. 280 24903 PMID: 15871945
If you know of a relevant reference for DIM-C-pPhOCH3, please let us know.
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Keywords: DIM-C-pPhOCH3, supplier, Nur77, NR4A1, agonists, agonism, NGFI-Balpha, α, apoptosis, memory, long-term, potentiation, LTP, Other, Nuclear, Receptors, Other, Transcription, Factors, Other, Nuclear, Receptors, Tocris Bioscience
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