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Cat.No. 6376 - DIM-C-pPhOCH3 | C24H20N2O | CAS No. 33985-68-1
Description: Nur77 agonist
Chemical Name: 1,1-Bis(3'-indolyl)-1-(p-methoxyphenyl)methane
Purity: ≥98% (HPLC)

Biological Activity

Nur77 agonist. Induces apoptosis in cancer cell lines in vitro. Enhances long-term potentiation in hippocampal slices and long-term contextual fear memory in an in vivo mouse model.

Technical Data

M. Wt 352.43
Formula C24H20N2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 33985-68-1
PubChem ID 11371604
Smiles COC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 352.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.19 mL 28.37 mL
5 mM 0.57 mL 2.84 mL 5.67 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Safety Datasheet


References are publications that support the biological activity of the product.

Bridi et al (2017) Pharmacological activators of the NR4A nuclear receptors enhance LTP in a CREB/CBP-dependent manner. Neuropsychopharmacology 42 1243 PMID: 27834392

Chintharlapalli et al (2005) Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J.Biol.Chem. 280 24903 PMID: 15871945

If you know of a relevant reference for DIM-C-pPhOCH3, please let us know.

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Keywords: DIM-C-pPhOCH3, DIM-C-pPhOCH3 supplier, Nur77, NR4A1, agonists, agonism, NGFI-Balpha, α, apoptosis, memory, long-term, potentiation, LTP, Other, Nuclear, Receptors, Transcription, Factors, 6376, Tocris Bioscience

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