Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewDIM-C-pPhOCH3
Discontinued Product
6376 has been discontinued.
View all Nerve Growth Factor IB-like Receptors products.
Description: Nur77 agonist
Chemical Name: 1,1-Bis(3'-indolyl)-1-(p-methoxyphenyl)methane
Purity: ≥98% (HPLC)
Biological Activity for DIM-C-pPhOCH3
DIM-C-pPhOCH3 is a Nur77 agonist. Induces apoptosis in cancer cell lines in vitro. Enhances long-term potentiation in hippocampal slices and long-term contextual fear memory in an in vivo mouse model.
Technical Data for DIM-C-pPhOCH3
| M. Wt | 352.43 |
| Formula | C24H20N2O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 33985-68-1 |
| PubChem ID | 11371604 |
| InChI Key | ZCCMKJAXOIFTHH-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DIM-C-pPhOCH3
References for DIM-C-pPhOCH3
References are publications that support the biological activity of the product.
Bridi et al (2017) Pharmacological activators of the NR4A nuclear receptors enhance LTP in a CREB/CBP-dependent manner. Neuropsychopharmacology 42 1243 PMID: 27834392
Chintharlapalli et al (2005) Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J.Biol.Chem. 280 24903 PMID: 15871945
View Related Products by Target
View Related Products by Product Action
Keywords: DIM-C-pPhOCH3, DIM-C-pPhOCH3 supplier, Nur77, NR4A1, agonists, agonism, NGFI-Balpha, α, apoptosis, memory, long-term, potentiation, LTP, Other, Transcription, Factors, Nerve, Growth, Factor, IB-like, Receptors, 6376, Tocris Bioscience
Citations for DIM-C-pPhOCH3
Citations are publications that use Tocris products.
Currently there are no citations for DIM-C-pPhOCH3.
Reviews for DIM-C-pPhOCH3
There are currently no reviews for this product. Be the first to review DIM-C-pPhOCH3 and earn rewards!
Have you used DIM-C-pPhOCH3?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for DIM-C-pPhOCH3
MAPK Signaling Pathway
The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.