Pricing Availability   Qty
Description: Nur77 agonist
Chemical Name: 1,1-Bis(3'-indolyl)-1-(p-methoxyphenyl)methane
Purity: ≥98% (HPLC)
Literature (1)
Pathways (1)

Biological Activity for DIM-C-pPhOCH3

DIM-C-pPhOCH3 is a Nur77 agonist. Induces apoptosis in cancer cell lines in vitro. Enhances long-term potentiation in hippocampal slices and long-term contextual fear memory in an in vivo mouse model.

Technical Data for DIM-C-pPhOCH3

M. Wt 352.43
Formula C24H20N2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 33985-68-1
PubChem ID 11371604
Smiles COC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DIM-C-pPhOCH3

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.24 100

Preparing Stock Solutions for DIM-C-pPhOCH3

The following data is based on the product molecular weight 352.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.19 mL 28.37 mL
5 mM 0.57 mL 2.84 mL 5.67 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets for DIM-C-pPhOCH3

References for DIM-C-pPhOCH3

References are publications that support the biological activity of the product.

Bridi et al (2017) Pharmacological activators of the NR4A nuclear receptors enhance LTP in a CREB/CBP-dependent manner. Neuropsychopharmacology 42 1243 PMID: 27834392

Chintharlapalli et al (2005) Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J.Biol.Chem. 280 24903 PMID: 15871945

If you know of a relevant reference for DIM-C-pPhOCH3, please let us know.

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Keywords: DIM-C-pPhOCH3, DIM-C-pPhOCH3 supplier, Nur77, NR4A1, agonists, agonism, NGFI-Balpha, α, apoptosis, memory, long-term, potentiation, LTP, Other, Transcription, Factors, Nerve, Growth, Factor, IB-like, Receptors, 6376, Tocris Bioscience

Citations for DIM-C-pPhOCH3

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for DIM-C-pPhOCH3

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.
NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.