Diazoxide

Pricing Availability   Qty
Cat.No. 0964 - Diazoxide | C8H7ClN2O2S | CAS No. 364-98-7
Description: Inhibits AMPA desensitization
Chemical Name: 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (10)

Biological Activity

Antihypertensive, activates ATP-dependent K+ channels (Kir6). Induces activation of PKCε, an intermediate in the opening of mitoKATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.

Compound Libraries

Diazoxide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 230.67
Formula C8H7ClN2O2S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 364-98-7
PubChem ID 3019
InChI Key GDLBFKVLRPITMI-UHFFFAOYSA-N
Smiles CC1=NC2=C(C=C(Cl)C=C2)S(=O)(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.07 100

Preparing Stock Solutions

The following data is based on the product molecular weight 230.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.34 mL 21.68 mL 43.35 mL
5 mM 0.87 mL 4.34 mL 8.67 mL
10 mM 0.43 mL 2.17 mL 4.34 mL
50 mM 0.09 mL 0.43 mL 0.87 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Kim et al (2006) Dox acts more as a PKC-ε activator, and indirectly activates the mitochondiral KATP channel conferring cardioprotection against hypoxic injury. Br.J.Pharmacol. 149 1059 PMID: 17043673

Trube et al (1986) Opposite effects of tolbut. and Dox on the ATP-dependent K+ channel in mouse pancreatic β-cells. Pflugers Arch. 407 493 PMID: 2431383

Yamada and Rothman (1992) Dox blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons. J.Physiol. 458 409 PMID: 1302270

Merck Index 12 3051


If you know of a relevant reference for Diazoxide, please let us know.

Keywords: Diazoxide, Diazoxide supplier, Blocks, desensitization, desensitisation, AMPA, receptors, K+, channel, opener, KATP, Glutamate, Receptors, iGlur, Ionotropic, Potassium, KIR, Kir6, Channels, Inward, Rectifier, rectifier, 0964, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Diazoxide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

4 Citations for Diazoxide

Citations are publications that use Tocris products. Selected citations for Diazoxide include:

Frazão et al (2013) Shift in Kiss1 cell activity requires estrogen receptor α. J Neurosci 33 2807 PMID: 23407940

Cox et al (2014) Chronic neonatal Dox therapy is not associated with adverse effects J Neurosci 14 49 PMID: 25587244

Niu et al (2011) Sex differences in the contribution of ATP-sensitive K+ channels in trigeminal ganglia under an acute muscle pain condition. Neuroscience 180 344 PMID: 21296645

Sun et al (2014) Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci Rep 4 4934 PMID: 24816792


Do you know of a great paper that uses Diazoxide from Tocris? Please let us know.

Reviews for Diazoxide

There are currently no reviews for this product. Be the first to review Diazoxide and earn rewards!

Have you used Diazoxide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Pain

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Alzheimer's

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Epilepsy

Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.

Learning & Memory

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.