Diazoxide

Pricing Availability Delivery Time Qty
Cat.No. 0964 - Diazoxide | C8H7ClN2O2S | CAS No. 364-98-7
Description: Blocks desensitization of AMPA receptors
Chemical Name: 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Antihypertensive, activates ATP-dependent K+ channels (Kir6). Induces activation of PKCε, an intermediate in the opening of mitoKATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.

Compound Libraries

Diazoxide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 230.67
Formula C8H7ClN2O2S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 364-98-7
PubChem ID 3019
InChI Key GDLBFKVLRPITMI-UHFFFAOYSA-N
Smiles CC1=NC2=C(C=C(Cl)C=C2)S(=O)(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.07 100

Preparing Stock Solutions

The following data is based on the product molecular weight 230.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.34 mL 21.68 mL 43.35 mL
5 mM 0.87 mL 4.34 mL 8.67 mL
10 mM 0.43 mL 2.17 mL 4.34 mL
50 mM 0.09 mL 0.43 mL 0.87 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kim et al (2006) Diazoxide acts more as a PKC-ε activator, and indirectly activates the mitochondiral KATP channel conferring cardioprotection against hypoxic injury. Br.J.Pharmacol. 149 1059 PMID: 17043673

Trube et al (1986) Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic β-cells. Pflugers Arch. 407 493 PMID: 2431383

Yamada and Rothman (1992) Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons. J.Physiol. 458 409 PMID: 1302270

Merck Index 12 3051 PMID:


If you know of a relevant reference for Diazoxide, please let us know.

Keywords: Blocks desensitization desensitisation AMPA receptors K+ channel opener KATP Glutamate Receptors iGlur Ionotropic Potassium KIR Kir6 Channels Inward Rectifier AMPA Receptors

1 Citation for Diazoxide

Citations are publications that use Tocris products. Selected citations for Diazoxide include:

Cox et al (2014) Chronic neonatal diazoxide therapy is not associated with adverse effects J Neurosci 14 49 PMID: 25587244


Do you know of a great paper that uses Diazoxide from Tocris? If so please let us know.

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Pathways for Diazoxide

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