Antihypertensive, activates ATP-dependent K+ channels (Kir6). Induces activation of PKCε, an intermediate in the opening of mitoKATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 230.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.34 mL||21.68 mL||43.35 mL|
|5 mM||0.87 mL||4.34 mL||8.67 mL|
|10 mM||0.43 mL||2.17 mL||4.34 mL|
|50 mM||0.09 mL||0.43 mL||0.87 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Kim et al (2006) Diazoxide acts more as a PKC-ε activator, and indirectly activates the mitochondiral KATP channel conferring cardioprotection against hypoxic injury. Br.J.Pharmacol. 149 1059 PMID: 17043673
Trube et al (1986) Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic β-cells. Pflugers Arch. 407 493 PMID: 2431383
Yamada and Rothman (1992) Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons. J.Physiol. 458 409 PMID: 1302270
If you know of a relevant reference for Diazoxide, please let us know.
View Related Products by Target
Keywords: Blocks desensitization desensitisation AMPA receptors K+ channel opener KATP Glutamate Receptors iGlur Ionotropic Potassium KIR Kir6 Channels Inward Rectifier AMPA Receptors
1 Citation for Diazoxide
Citations are publications that use Tocris products. Selected citations for Diazoxide include:
Cox et al (2014) Chronic neonatal diazoxide therapy is not associated with adverse effects J Neurosci 14 49 PMID: 25587244
Do you know of a great paper that uses Diazoxide from Tocris? If so please let us know.
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