Diazepam binding inhibitory fragment

Name: Diazepam binding inhibitory fragment
Brand: Tocris Bioscience
SKU: 1888

Cat. No. 1888 Submit a Review Datasheet / COA / SDS

Discontinued Product

Diazepam binding inhibitory fragment (Cat. No. 1888) has been withdrawn from sale for commercial reasons.

Description: Peripheral benzodiazepine receptor agonist

Alternative Names: DBI (51-70) (human), Eikosaneuropeptide, ENP

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Citations

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Literature (3)

Biological Activity Technical Data Datasheets References

Biological Activity for Diazepam binding inhibitory fragment

Peptide fragment corresponding to residues 51-70 of the human diazepam binding inhibitor protein; peripheral benzodiazepine receptor agonist. Induces intracellular Ca²⁺ increase and phagocytosis in human neutrophils, mainly through a non-peripheral benzodiazepine receptor-mediated mechanism. Also reduces ammonia-induced swelling in cultured astrocytes.

Technical Data for Diazepam binding inhibitory fragment

M. Wt	2150.39
Formula	C₉₁H₁₄₈N₂₆O₃₂S
Storage	Desiccate at -20°C
CAS Number	104360-70-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Diazepam binding inhibitory fragment

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References for Diazepam binding inhibitory fragment

References are publications that support the biological activity of the product.

Bender and Norenberg (1998) Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes. J.Neurosci.Res. 54 673 PMID: 9843158

Cosentino et al (2000) D.pam-binding inhibitor-derived peptides induce intracellular calcium changes and modulate human neutrophil function. J.Leukoc.Biol. 67 637 PMID: 10811003

Gray et al (1986) Cloning and expression of cDNA for human D.pam binding inhibitor, a natural ligand of an allosteric regulatory site of the γ-aminobutyric acid type A receptor. Proc.Natl.Acad.Sci.U.S.A. 83 7547 PMID: 3020548

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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GABA Receptors Scientific Review

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