Diazepam binding inhibitory fragment
Discontinued ProductUnfortunately Diazepam binding inhibitory fragment (Cat. No. 1888) has been withdrawn from sale for commercial reasons.
Peptide fragment corresponding to residues 51-70 of the human diazepam binding inhibitor protein; peripheral benzodiazepine receptor agonist. Induces intracellular Ca2+ increase and phagocytosis in human neutrophils, mainly through a non-peripheral benzodiazepine receptor-mediated mechanism. Also reduces ammonia-induced swelling in cultured astrocytes.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 2150.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.47 mL||2.33 mL||4.65 mL|
|5 mM||0.09 mL||0.47 mL||0.93 mL|
|10 mM||0.05 mL||0.23 mL||0.47 mL|
|50 mM||0.01 mL||0.05 mL||0.09 mL|
References are publications that support the products' biological activity.
Bender and Norenberg (1998) Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes. J.Neurosci.Res. 54 673 PMID: 9843158
Cosentino et al (2000) Diazepam-binding inhibitor-derived peptides induce intracellular calcium changes and modulate human neutrophil function. J.Leukoc.Biol. 67 637 PMID: 10811003
Gray et al (1986) Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the γ-aminobutyric acid type A receptor. Proc.Natl.Acad.Sci.U.S.A. 83 7547 PMID: 3020548
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