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Discontinued Product
Diazepam binding inhibitory fragment (Cat. No. 1888) has been withdrawn from sale for commercial reasons.
Description: Peripheral benzodiazepine receptor agonist
Alternative Names: DBI (51-70) (human), Eikosaneuropeptide, ENP
Biological Activity for Diazepam binding inhibitory fragment
Peptide fragment corresponding to residues 51-70 of the human diazepam binding inhibitor protein; peripheral benzodiazepine receptor agonist. Induces intracellular Ca2+ increase and phagocytosis in human neutrophils, mainly through a non-peripheral benzodiazepine receptor-mediated mechanism. Also reduces ammonia-induced swelling in cultured astrocytes.
Technical Data for Diazepam binding inhibitory fragment
| M. Wt | 2150.39 |
| Formula | C91H148N26O32S |
| Storage | Desiccate at -20°C |
| CAS Number | 104360-70-5 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Diazepam binding inhibitory fragment
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References for Diazepam binding inhibitory fragment
References are publications that support the biological activity of the product.
Bender and Norenberg (1998) Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes. J.Neurosci.Res. 54 673 PMID: 9843158
Cosentino et al (2000) D.pam-binding inhibitor-derived peptides induce intracellular calcium changes and modulate human neutrophil function. J.Leukoc.Biol. 67 637 PMID: 10811003
Gray et al (1986) Cloning and expression of cDNA for human D.pam binding inhibitor, a natural ligand of an allosteric regulatory site of the γ-aminobutyric acid type A receptor. Proc.Natl.Acad.Sci.U.S.A. 83 7547 PMID: 3020548
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