Deferoxamine mesylate

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Cat.No. 5764 - Deferoxamine mesylate | C25H48N6O8.CH4O3S | CAS No. 138-14-7
Description: Iron chelator; also hypoxia mimetic
Chemical Name: N4-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxybutanediamide methanesulfonate
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Citations
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Literature

Biological Activity

Iron chelator. Also hypoxia mimetic and inhibitor of ferroptosis

Technical Data

M. Wt 656.79
Formula C25H48N6O8.CH4O3S
Storage Store at -20°C
CAS Number 138-14-7
PubChem ID 62881
InChI Key IDDIJAWJANBQLJ-UHFFFAOYSA-N
Smiles ON(C(CCC(NCCCCCN(C(CCC(NCCCCCN(O)C(C)=O)=O)=O)O)=O)=O)CCCCCN.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 65.68 100

Preparing Stock Solutions

The following data is based on the product molecular weight 656.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.52 mL 7.61 mL 15.23 mL
5 mM 0.3 mL 1.52 mL 3.05 mL
10 mM 0.15 mL 0.76 mL 1.52 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

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References

References are publications that support the biological activity of the product.

Chau et al (2005) Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors. Cancer Res 65 4918 PMID: 15930314


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