Deferoxamine mesylate

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Description: Iron chelator; also hypoxia mimetic and neuroprotectant
Chemical Name: N4-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxybutanediamide methanesulfonate

Biological Activity for Deferoxamine mesylate

Deferoxamine mesylate is an iron chelator. Also hypoxia mimetic and inhibitor of ferroptosis. Has neuroprotective effects in animal models of stroke, traumatic brain injury and neurodegenerative diseases.

Technical Data for Deferoxamine mesylate

M. Wt 656.79
Formula C25H48N6O8.CH4O3S
Storage Store at -20°C
CAS Number 138-14-7
PubChem ID 62881

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Deferoxamine mesylate

Solvent Max Conc. mg/mL Max Conc. mM
water 65.68 100

Preparing Stock Solutions for Deferoxamine mesylate

The following data is based on the product molecular weight 656.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.52 mL 7.61 mL 15.23 mL
5 mM 0.3 mL 1.52 mL 3.05 mL
10 mM 0.15 mL 0.76 mL 1.52 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

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Product Datasheets for Deferoxamine mesylate

Certificate of Analysis / Product Datasheet
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References for Deferoxamine mesylate

References are publications that support the biological activity of the product.

Chau et al (2005) Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors. Cancer Res. 65 4918 PMID: 15930314

Kosyakovsky et al (2019) Quantifying intranasally administered deferoxamine in rat brain tissue with mass spectrometry. ACS Chem.Neurosci. 10 4571 PMID: 31573798

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