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Stimulates Cl- secretion via the activation of hKCa3.1 (IK1) potassium channels and an apical Cl- conductance carried by the CFTR channel. More potent than its analog 1-EBIO (Cat. No. 1041).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 231.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.33 mL||21.64 mL||43.28 mL|
|5 mM||0.87 mL||4.33 mL||8.66 mL|
|10 mM||0.43 mL||2.16 mL||4.33 mL|
|50 mM||0.09 mL||0.43 mL||0.87 mL|
References are publications that support the biological activity of the product.
Singh et al (2001) Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J.Pharmacol.Exp.Ther. 296 600 PMID: 11160649
Hamilton and Kiessling et al (2006) DCEBIO stimulates Cl- secretion in the mouse jejunum. Am.J.Physiol.Cell Physiol. 290 152 PMID: 16135545
If you know of a relevant reference for DCEBIO, please let us know.
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Keywords: DCEBIO, DCEBIO supplier, potent, Activators, hIK1/Cl-, conductance, K+, channels, Potassium, KCa, KCa3.1, Channels, ca2+-activated, ca2+-dependent, Chloride, Ca2+-Activated, CFTR, 1422, Tocris Bioscience
5 Citations for DCEBIO
Citations are publications that use Tocris products. Selected citations for DCEBIO include:
MacVinish et al (2007) Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR. J Reprod Dev 150 1055 PMID: 17339840
Fioretti et al (2005) Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis. Am J Physiol Cell Physiol 289 C89 PMID: 15743891
Hirota and McKay (2009) Loss of Ca-mediated ion transport during colitis correlates with reduced ion transport responses to a Ca-activated K channel opener. Br J Pharmacol 156 1085 PMID: 19298254
McCully et al (2015) Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells. J Immunol 195 96 PMID: 26002980
Laube et al (2013) Benzimidazolones enhance the function of epithelial Na+ transport. Br J Pharmacol 168 1329 PMID: 23083067
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