DCEBIO

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Cat.No. 1422 - DCEBIO | C9H8Cl2N2O | CAS No. 60563-36-2
Description: Activates Cl- conductance and hKCa3.1 channels
Chemical Name: 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (1)

Biological Activity

Stimulates Cl- secretion via the activation of hKCa3.1 (IK1) potassium channels and an apical Cl- conductance carried by the CFTR channel. More potent than its analog 1-EBIO (Cat. No. 1041).

Compound Libraries

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Technical Data

M. Wt 231.08
Formula C9H8Cl2N2O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 60563-36-2
PubChem ID 656765
InChI Key LKHRMULASXZCLG-UHFFFAOYSA-N
Smiles CCN1C(=O)NC2=C1C=C(Cl)C(Cl)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.11 100
ethanol 23.11 100

Preparing Stock Solutions

The following data is based on the product molecular weight 231.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.33 mL 21.64 mL 43.28 mL
5 mM 0.87 mL 4.33 mL 8.66 mL
10 mM 0.43 mL 2.16 mL 4.33 mL
50 mM 0.09 mL 0.43 mL 0.87 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Singh et al (2001) Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J.Pharmacol.Exp.Ther. 296 600 PMID: 11160649

Hamilton and Kiessling et al (2006) DCEBIO stimulates Cl- secretion in the mouse jejunum. Am.J.Physiol.Cell Physiol. 290 152 PMID: 16135545


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View Related Products by Product Action

View all CFTR Activators

Keywords: DCEBIO, DCEBIO supplier, potent, Activators, hIK1/Cl-, conductance, K+, channels, Potassium, KCa, KCa3.1, Channels, ca2+-activated, ca2+-dependent, Chloride, Ca2+-Activated, CFTR, 1422, Tocris Bioscience

5 Citations for DCEBIO

Citations are publications that use Tocris products. Selected citations for DCEBIO include:

McCully et al (2015) Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells. J Immunol 195 96 PMID: 26002980

Hirota and McKay (2009) Loss of Ca-mediated ion transport during colitis correlates with reduced ion transport responses to a Ca-activated K channel opener. Br J Pharmacol 156 1085 PMID: 19298254

Laube et al (2013) Benzimidazolones enhance the function of epithelial Na+ transport. Br J Pharmacol 168 1329 PMID: 23083067

MacVinish et al (2007) Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR. J Reprod Dev 150 1055 PMID: 17339840

Fioretti et al (2005) Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis. Am J Physiol Cell Physiol 289 C89 PMID: 15743891


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Literature in this Area

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Ion Channel

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