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Description: Activates Cl- conductance and hKCa3.1 channels
Chemical Name: 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Purity: ≥99% (HPLC)
Citations (5)

Biological Activity for DCEBIO

DCEBIO is a stimulates Cl- secretion via the activation of hKCa3.1 (IK1) potassium channels and an apical Cl- conductance carried by the CFTR channel. More potent than its analog 1-EBIO (Cat. No. 1041).

Compound Libraries for DCEBIO

DCEBIO is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DCEBIO

M. Wt 231.08
Formula C9H8Cl2N2O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 60563-36-2
PubChem ID 656765
Smiles CCN1C(=O)NC2=C1C=C(Cl)C(Cl)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DCEBIO

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 23.11 100
DMSO 23.11 100

Preparing Stock Solutions for DCEBIO

The following data is based on the product molecular weight 231.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.33 mL 21.64 mL 43.28 mL
5 mM 0.87 mL 4.33 mL 8.66 mL
10 mM 0.43 mL 2.16 mL 4.33 mL
50 mM 0.09 mL 0.43 mL 0.87 mL

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Product Datasheets for DCEBIO

Certificate of Analysis / Product Datasheet
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References for DCEBIO

References are publications that support the biological activity of the product.

Singh et al (2001) Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J.Pharmacol.Exp.Ther. 296 600 PMID: 11160649

Hamilton and Kiessling et al (2006) DCEBIO stimulates Cl- secretion in the mouse jejunum. Am.J.Physiol.Cell Physiol. 290 152 PMID: 16135545

If you know of a relevant reference for DCEBIO, please let us know.

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Keywords: DCEBIO, DCEBIO supplier, potent, Activators, hIK1/Cl-, conductance, K+, channels, Potassium, KCa, KCa3.1, Channels, ca2+-activated, ca2+-dependent, Chloride, Ca2+-Activated, CFTR, 1422, Tocris Bioscience

5 Citations for DCEBIO

Citations are publications that use Tocris products. Selected citations for DCEBIO include:

McCully et al (2015) Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells. J Immunol 195 96 PMID: 26002980

Laube et al (2013) Benzimidazolones enhance the function of epithelial Na+ transport. Br J Pharmacol 168 1329 PMID: 23083067

Fioretti et al (2005) Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis. Am J Physiol Cell Physiol 289 C89 PMID: 15743891

MacVinish et al (2007) Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR. J Reprod Dev 150 1055 PMID: 17339840

Do you know of a great paper that uses DCEBIO from Tocris? Please let us know.

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