DCEBIO

Pricing Availability Delivery Time Qty
Cat.No. 1422 - DCEBIO | C9H8Cl2N2O | CAS No. 60563-36-2
Description: Activates Cl- conductance and hKCa3.1 channels
Chemical Name: 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Stimulates Cl- secretion via the activation of hKCa3.1 (IK1) potassium channels and an apical Cl- conductance carried by the CFTR channel. More potent than its analog 1-EBIO (Cat. No. 1041).

Compound Libraries

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Technical Data

M. Wt 231.08
Formula C9H8Cl2N2O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 60563-36-2
PubChem ID 656765
InChI Key LKHRMULASXZCLG-UHFFFAOYSA-N
Smiles CCN1C(=O)NC2=C1C=C(Cl)C(Cl)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.11 100
ethanol 23.11 100

Preparing Stock Solutions

The following data is based on the product molecular weight 231.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.33 mL 21.64 mL 43.28 mL
5 mM 0.87 mL 4.33 mL 8.66 mL
10 mM 0.43 mL 2.16 mL 4.33 mL
50 mM 0.09 mL 0.43 mL 0.87 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Singh et al (2001) Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J.Pharmacol.Exp.Ther. 296 600 PMID: 11160649

Hamilton and Kiessling et al (2006) DCEBIO stimulates Cl- secretion in the mouse jejunum. Am.J.Physiol.Cell Physiol. 290 152 PMID: 16135545


If you know of a relevant reference for DCEBIO, please let us know.

View Related Products by Product Action

View all CFTR Activators

Keywords: DCEBIO, supplier, potent, Activators, hIK1/Cl-, conductance, K+, channels, Potassium, KCa, KCa3.1, Channels, ca2+-activated, ca2+-dependent, Chloride, Ca2+-Activated, Potassium, Channels, CFTR, CFTR, Tocris Bioscience

3 Citations for DCEBIO

Citations are publications that use Tocris products. Selected citations for DCEBIO include:

Laube et al (2013) Benzimidazolones enhance the function of epithelial Na+ transport. Br J Pharmacol 168 1329 PMID: 23083067

MacVinish et al (2007) Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR. J Reprod Dev 150 1055 PMID: 17339840

McCully et al (2015) Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells. J Immunol 195 96 PMID: 26002980


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Literature in this Area

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