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Description: Reagent for synthetic biology; converts cysteine to dehydroalanine
Chemical Name: 2,5-Dibromohexanediamide
Citations (1)

Biological Activity for DBHDA

DBHDA is a reagent for synthetic biology; converts cysteine to dehydroalanine (Dha).

Technical Data for DBHDA

M. Wt 301.96
Formula C6H10Br2N2O2
Storage Store at +4°C
CAS Number 99584-96-0
PubChem ID 277410
Smiles NC(C(CCC(C(N)=O)Br)Br)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DBHDA

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.2 100

Preparing Stock Solutions for DBHDA

The following data is based on the product molecular weight 301.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.56 mL 33.12 mL
5 mM 0.66 mL 3.31 mL 6.62 mL
10 mM 0.33 mL 1.66 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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References for DBHDA

References are publications that support the biological activity of the product.

Chalker et al (2011) Methods for converting cysteine to dehydroalanine on peptides and proteins. Chem. Sci. 2 1666

Wright et al (2016) Posttranslational mutagenesis: a chemical strategy for exploring protein side-chain diversity. Science 354 1465 PMID: 27708059

Mulder et al (2016) A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes. Nat.Chem.Biol. 12 523 PMID: 27182664

Lercher et al (2015) Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation. Nat.Commun. 25 7978 PMID: 26305776

If you know of a relevant reference for DBHDA, please let us know.

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Keywords: DBHDA, DBHDA supplier, diacetamide, reagent, synthetic, biology, converts, cysteine, dehydroalanine, Dha, Biochemicals, and, Molecular, Biology, 6175, Tocris Bioscience

1 Citation for DBHDA

Citations are publications that use Tocris products. Selected citations for DBHDA include:

Andrew J et al (2023) Posttranslational, site-directed photochemical fluorine editing of protein sidechains to probe residue oxidation state via 19F-nuclear magnetic resonance. Nat Protoc 18 1543-1562 PMID: 36806799

Do you know of a great paper that uses DBHDA from Tocris? Please let us know.

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