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Cat.No. 4417 - DBeQ | C22H20N4 | CAS No. 177355-84-9
Description: Selective and reversible p97 ATPase inhibitor
Chemical Name: N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine
Purity: ≥99% (HPLC)

Biological Activity

Selective and reversible inhibitor of p97 ATPase (VCP, IC50 = 1.5 μM). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II.

Compound Libraries

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Technical Data

M. Wt 340.42
Formula C22H20N4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 177355-84-9
PubChem ID 676352
Smiles C12=CC=CC=C1N=C(NCC4=CC=CC=C4)N=C2NCC3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.04 100
ethanol 6.81 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 340.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.38 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Chou et al (2011) Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc.Natl.Acad.Sci.USA 108 4834 PMID: 21383145

Chou and Deshaies (2011) Development of p97 AAA ATPase inhibitors. Autophagy 7 1091 PMID: 21606684

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Citations for DBeQ

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Literature in this Area


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Pathways for DBeQ


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