Pricing Availability   Qty
Description: Selective and reversible p97 ATPase inhibitor
Chemical Name: N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine
Purity: ≥99% (HPLC)
Citations (2)
Reviews (1)
Literature (1)

Biological Activity for DBeQ

DBeQ is a selective and reversible inhibitor of p97 ATPase (VCP, IC50 = 1.5 μM). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II.

Compound Libraries for DBeQ

DBeQ is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DBeQ

M. Wt 340.42
Formula C22H20N4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 177355-84-9
PubChem ID 676352
Smiles C12=CC=CC=C1N=C(NCC4=CC=CC=C4)N=C2NCC3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DBeQ

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.04 100

Preparing Stock Solutions for DBeQ

The following data is based on the product molecular weight 340.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.38 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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References for DBeQ

References are publications that support the biological activity of the product.

Chou et al (2011) Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc.Natl.Acad.Sci.USA 108 4834 PMID: 21383145

Chou and Deshaies (2011) Development of p97 AAA ATPase inhibitors. Autophagy 7 1091 PMID: 21606684

If you know of a relevant reference for DBeQ, please let us know.

View Related Products by Product Action

View all p97 ATPase Inhibitors

Keywords: DBeQ, DBeQ supplier, DBeQ, aaa, atpases, p97, reversible, reversibly, selective, inhibitors, inhibits, autophagy, erad, endoplasmic-reticulum, associated, protein, degradation, Autophagy, Other, ER, stress/UPR, ATPase, Translocation, 4417, Tocris Bioscience

2 Citations for DBeQ

Citations are publications that use Tocris products. Selected citations for DBeQ include:

Tiwari et al (2016) Caveolin-1 is an aggresome-inducing protein. Sci Rep 6 38681 PMID: 27929047

Keith et al (2022) Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. Nat Commun 13 4146 PMID: 35842429

Do you know of a great paper that uses DBeQ from Tocris? Please let us know.

Reviews for DBeQ

Average Rating: 3 (Based on 1 Review.)

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DbeQ on Dictyostelium mTORC1 signalling.
By Eleanor Warren on 05/23/2019
Assay Type: In Vitro
Species: Other

Treated Dictyostelium cells with DbeQ at 15 uM and 1.5 uM concentrations for 1 hour or 24 hours, and monitored p-4E-BP1 levels as a readout for mTORc1 activity. Did not see any significant difference from control

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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