Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewDBeQ
Description: Selective and reversible p97 ATPase inhibitor
Chemical Name: N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine
Purity: ≥99% (HPLC)
Biological Activity for DBeQ
DBeQ is a selective and reversible inhibitor of p97 ATPase (VCP, IC50 = 1.5 μM). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II.
Compound Libraries for DBeQ
DBeQ is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for DBeQ
| M. Wt | 340.42 |
| Formula | C22H20N4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 177355-84-9 |
| PubChem ID | 676352 |
| InChI Key | QAIMUUJJAJBPCL-UHFFFAOYSA-N |
| Smiles | C12=CC=CC=C1N=C(NCC4=CC=CC=C4)N=C2NCC3=CC=CC=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DBeQ
References for DBeQ
References are publications that support the biological activity of the product.
Chou et al (2011) Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc.Natl.Acad.Sci.USA 108 4834 PMID: 21383145
Chou and Deshaies (2011) Development of p97 AAA ATPase inhibitors. Autophagy 7 1091 PMID: 21606684
View Related Products by Target
View Related Products by Product Action
Keywords: DBeQ, DBeQ supplier, DBeQ, aaa, atpases, p97, reversible, reversibly, selective, inhibitors, inhibits, autophagy, erad, endoplasmic-reticulum, associated, protein, degradation, Autophagy, Other, ER, stress/UPR, ATPase, Translocation, 4417, Tocris Bioscience
2 Citations for DBeQ
Citations are publications that use Tocris products. Selected citations for DBeQ include:
Keith et al (2022) Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. Nat Commun 13 4146 PMID: 35842429
Tiwari et al (2016) Caveolin-1 is an aggresome-inducing protein. Sci Rep 6 38681 PMID: 27929047
Reviews for DBeQ
Average Rating: 3 (Based on 1 Review.)
Have you used DBeQ?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
DbeQ on Dictyostelium mTORC1 signalling.
By
Eleanor Warren on 05/23/2019
Assay Type: In Vitro
Species: Dictyostelium
Treated Dictyostelium cells with DbeQ at 15 uM and 1.5 uM concentrations for 1 hour or 24 hours, and monitored p-4E-BP1 levels as a readout for mTORc1 activity. Did not see any significant difference from control
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.