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Description: Amine reactive and azide reactive building block
Chemical Name: 2,5-Dioxo-1-pyrrolidinyl-11,12-didehydro-γ-oxodibenz[b,f]azocine-5(6H)-butanoate
Purity: ≥95% (HPLC)

Biological Activity for DBCO-NHS

DBCO-NHS is an amine reactive and azide reactive building block. It can be used for copper-free click cycloaddition reactions.

Usage Guidelines for DBCO-NHS

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for DBCO-NHS

M. Wt 402.4
Formula C23H18N2O5
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1353016-71-3
PubChem ID 77078178
Smiles O=C(ON1C(=O)CCC1=O)CCC(=O)N2C=3C=CC=CC3C#CC=4C=CC=CC4C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for DBCO-NHS

References are publications that support the biological activity of the product.

Liu et al (2012) Strain-promoted "click" modification of a mesoporous metal-organic framework. J.Am.Chem.Soc. 134 18886 PMID: 23113571

Ge et al (2022) Chemoselective bioconjugation of amyloidogenic protein antigens to PEGylated microspheres enables detection of α-Synuclein autoantibodies in human plasma. Bioconjug.Chem. 33 301 PMID: 35020392

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Citations for DBCO-NHS

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