D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt

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Cat.No. 1420 - D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt | C6H8O18P4.K8 | CAS No. 145843-69-2
Description: Potent inhibitor of Ins(1,4,5)P3 5-phosphatase. Metabolite of Cat. No. 1482
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Phosphorylation product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P3). Potent inhibitor of Ins (1,4,5)P3 5-phosphatase (IC50 ~150 nM); facilitates Ca2+ influx by sensitizing Ins (1,4,5)P3-mediated activation of ICRAC. At higher concentrations, acts as an inhibitor of Ins (1,4,5)P3 receptors.

Technical Data

M. Wt 804.73
Formula C6H8O18P4.K8
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 145843-69-2
PubChem ID 16760517
InChI Key HDLWTQSZUMYYND-QAVKKEKOSA-F
Smiles [K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].O[C@H]1[C@@H](OP([O-])([O-])=O)[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H]1OP([O-])([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in water

Preparing Stock Solutions

The following data is based on the product molecular weight 804.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.24 mL 6.21 mL 12.43 mL
5 mM 0.25 mL 1.24 mL 2.49 mL
10 mM 0.12 mL 0.62 mL 1.24 mL
50 mM 0.02 mL 0.12 mL 0.25 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Balla et al (1991) Agonist-induced calcium signaling is impaired in fibroblasts overproducing inositol 1,3,4,5-tetrakisphosphate. J.Biol.Chem. 266 24719 PMID: 1662215

Cullen et al (1998) Bridging the GAP in inositol 1,3,4,5-tetrakisphosphate signalling. Biochim.Biophys.Acta 1436 35 PMID: 9838034

Hermosura et al (2000) InsP4 facilitates store-operated calcium influx by inhibition of InsP3 5-phosphatase. Nature 408 735 PMID: 11130077


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Keywords: Potent inhibitors inhibits Ins145P3 5-phosphatase Inositol Phosphatases

Citations for D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt

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