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D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt is a phosphorylation product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P3). Potent inhibitor of Ins (1,4,5)P3 5-phosphatase (IC50 ~150 nM); facilitates Ca2+ influx by sensitizing Ins (1,4,5)P3-mediated activation of ICRAC. At higher concentrations, acts as an inhibitor of Ins (1,4,5)P3 receptors.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Balla et al (1991) Agonist-induced calcium signaling is impaired in fibroblasts overproducing inositol 1,3,4,5-tetrakisphosphate. J.Biol.Chem. 266 24719 PMID: 1662215
Cullen et al (1998) Bridging the GAP in inositol 1,3,4,5-tetrakisphosphate signalling. Biochim.Biophys.Acta 1436 35 PMID: 9838034
Hermosura et al (2000) InsP4 facilitates store-operated calcium influx by inhibition of InsP3 5-phosphatase. Nature 408 735 PMID: 11130077
Keywords: D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt, D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt supplier, Potent, inhibitors, inhibits, Ins145P3, 5-phosphatase, Inositol, Lipids, Phosphatases, 1420, Tocris Bioscience
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