D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt
Phosphorylation product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P3). Potent inhibitor of Ins (1,4,5)P3 5-phosphatase (IC50 ~150 nM); facilitates Ca2+ influx by sensitizing Ins (1,4,5)P3-mediated activation of ICRAC. At higher concentrations, acts as an inhibitor of Ins (1,4,5)P3 receptors.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 804.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.24 mL||6.21 mL||12.43 mL|
|5 mM||0.25 mL||1.24 mL||2.49 mL|
|10 mM||0.12 mL||0.62 mL||1.24 mL|
|50 mM||0.02 mL||0.12 mL||0.25 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Balla et al (1991) Agonist-induced calcium signaling is impaired in fibroblasts overproducing inositol 1,3,4,5-tetrakisphosphate. J.Biol.Chem. 266 24719 PMID: 1662215
Cullen et al (1998) Bridging the GAP in inositol 1,3,4,5-tetrakisphosphate signalling. Biochim.Biophys.Acta 1436 35 PMID: 9838034
Hermosura et al (2000) InsP4 facilitates store-operated calcium influx by inhibition of InsP3 5-phosphatase. Nature 408 735 PMID: 11130077
If you know of a relevant reference for D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt, please let us know.
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Keywords: Potent inhibitors inhibits Ins145P3 5-phosphatase Inositol Phosphatases
Citations for D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt
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