D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt

Pricing Availability   Qty
Description: Ca2+ mobilizing second messenger
Citations (1)
Literature (1)

Biological Activity

D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt is an important second messenger involved in Ca2+ mobilization from intracellular stores (EC50 = 0.1 μM). Formed from the enzymatic hydrolysis of phosphatidyl inositol-4,5-bisphosphate.

Technical Data

M. Wt 648.64
Formula C6H9O15P3.K6
Storage Store at -20°C
CAS Number 103476-24-0
PubChem ID 16219525
Smiles [K+].[K+].[K+].[K+].[K+].[K+].O[C@@H]1[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@@H](O)[C@@H]1OP([O-])([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Joseph et al (1984) myo-Inositol 1,4,5-trisphosphate. J.Biol.Chem. 259 3077 PMID: 6607924

Murphy et al (1996) Enantiomers of myo-inositol-1,3,4-trisphosphate and myo-inositol-1,4,6-trisphosphate: stereospecific recognition by cerebellar and platelet myo-inositol-1,4,5-trisphosphate receptors. Mol.Pharmacol. 50 1223 PMID: 8913354

Wilcox et al (1998) New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor. TiPS 19 467 PMID: 9850611

If you know of a relevant reference for D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt, please let us know.

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1 Citation for D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt

Citations are publications that use Tocris products. Selected citations for D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt include:

Li et al (2016) Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated Ins secretion. Cell Death Dis 7 e2275 PMID: 27336719

Do you know of a great paper that uses D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt from Tocris? Please let us know.

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Literature in this Area

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