CY 208-243

Pricing Availability   Qty
Description: Selective D1-like agonist
Chemical Name: (-)-(6aR,12bR)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-a]phenanthridin
Literature (4)

Biological Activity for CY 208-243

CY 208-243 is a centrally active dopamine D1 receptor agonist, selective over D2 receptor sites. Stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM. Unlike SKF 38393 (Cat. No. 0922), it exerts antiParkinsonian activity in animal models.

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data for CY 208-243

M. Wt 274.36
Formula C19H18N2
Storage Store at RT
CAS Number 100999-26-6
PubChem ID 58144
Smiles [H][C@]4([C@@]([H])3C5=C(C=CC=C5)CN4C)CC1=CNC2=C1C3=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CY 208-243

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 100

Preparing Stock Solutions for CY 208-243

The following data is based on the product molecular weight 274.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.64 mL 18.22 mL 36.45 mL
5 mM 0.73 mL 3.64 mL 7.29 mL
10 mM 0.36 mL 1.82 mL 3.64 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for CY 208-243

References are publications that support the biological activity of the product.

Andersen and Jansen (1990) DA receptor agonists: selectivity and DA D1 receptor efficacy. Eur.J.Pharmacol. 188 335 PMID: 1973652

Temlett et al (1989) Antiparkinsonian activity of CY 208-243, a partial D-1 DA receptor agonist, in MPTP-treated marmosets and patients with Parkinson's disease. Mov.Disord. 4 261 PMID: 2571082

Markstein et al (1988) Pharmacologic properties of CY 208-243, a novel D1 agonist. Progress in Catecholamine Research. Part B. Centra 59-64

If you know of a relevant reference for CY 208-243, please let us know.

View Related Products by Target

View Related Products by Product Action

View all D1 and D5 Receptor Agonists

Keywords: CY 208-243, CY 208-243 supplier, Selective, D1-like, agonists, Dopamine, D1, Receptors, D5, dopaminergic, CY208-243, and, 1249, Tocris Bioscience

Citations for CY 208-243

Citations are publications that use Tocris products.

Currently there are no citations for CY 208-243. Do you know of a great paper that uses CY 208-243 from Tocris? Please let us know.

Reviews for CY 208-243

There are currently no reviews for this product. Be the first to review CY 208-243 and earn rewards!

Have you used CY 208-243?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.