CY 208-243

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Cat.No. 1249 - CY 208-243 | C19H18N2 | CAS No. 100999-26-6
Description: Selective D1-like agonist
Chemical Name: (-)-(6aR,12bR)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-a]phenanthridin
Datasheet
Citations
Reviews
Literature

Biological Activity

Centrally active dopamine D1 receptor agonist, selective over D2 receptor sites. Stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM. Unlike SKF 38393 (Cat. No. 0922), it exerts antiParkinsonian activity in animal models.

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data

M. Wt 274.36
Formula C19H18N2
Storage Store at RT
CAS Number 100999-26-6
PubChem ID 58144
InChI Key WRNKIDLXXXIELU-IEBWSBKVSA-N
Smiles [H][C@]4([C@@]([H])3C5=C(C=CC=C5)CN4C)CC1=CNC2=C1C3=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 274.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.64 mL 18.22 mL 36.45 mL
5 mM 0.73 mL 3.64 mL 7.29 mL
10 mM 0.36 mL 1.82 mL 3.64 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Andersen and Jansen (1990) Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy. Eur.J.Pharmacol. 188 335 PMID: 1973652

Temlett et al (1989) Antiparkinsonian activity of CY 208-243, a partial D-1 dopamine receptor agonist, in MPTP-treated marmosets and patients with Parkinson's disease. Mov.Disord. 4 261 PMID: 2571082

Markstein et al (1988) Pharmacologic properties of CY 208-243, a novel D1 agonist. Progress in Catecholamine Research. Part B. Centra 59-64 PMID:


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Keywords: CY 208-243, supplier, Selective, D1-like, agonists, Dopamine, D1, Receptors, D5, dopaminergic, CY208-243, D1, and, D5, Receptors, D1, and, D5, Receptors, Tocris Bioscience

Citations for CY 208-243

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