Centrally active dopamine D1 receptor agonist, selective over D2 receptor sites. Stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM. Unlike SKF 38393 (Cat. No. 0922), it exerts antiParkinsonian activity in animal models.
Sold with the permission of Novartis Pharma AG
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 274.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.64 mL||18.22 mL||36.45 mL|
|5 mM||0.73 mL||3.64 mL||7.29 mL|
|10 mM||0.36 mL||1.82 mL||3.64 mL|
|50 mM||0.07 mL||0.36 mL||0.73 mL|
References are publications that support the products' biological activity.
Andersen and Jansen (1990) Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy. Eur.J.Pharmacol. 188 335 PMID: 1973652
Temlett et al (1989) Antiparkinsonian activity of CY 208-243, a partial D-1 dopamine receptor agonist, in MPTP-treated marmosets and patients with Parkinson's disease. Mov.Disord. 4 261 PMID: 2571082
If you know of a relevant reference for CY 208-243, please let us know.
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Keywords: CY 208-243, supplier, Selective, D1-like, agonists, Dopamine, D1, Receptors, D5, dopaminergic, CY208-243, D1, and, D5, Receptors, D1, and, D5, Receptors, Tocris Bioscience
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Literature in this Area
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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