Cucurbitacin I

Pricing Availability   Qty
Description: Selective inhibitor of STAT3/JAK2 signaling
Alternative Names: Elatericin B,JSI 124
Chemical Name: (9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
Purity: ≥95% (HPLC)
Citations (8)
Pathways (1)

Biological Activity for Cucurbitacin I

Cucurbitacin I is a selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

Technical Data for Cucurbitacin I

M. Wt 514.65
Formula C30H42O7
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2222-07-3
PubChem ID 5281321
Smiles OC(C)(C)/C=C/C([C@@](O)(C)[C@@]3([H])[C@H](O)C[C@@]([C@@](C)3C4)(C)[C@]2([H])CC=C1C(C)(C)C(C(O)=C[C@]([H])1[C@@](C)2C4=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cucurbitacin I

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.15 10

Preparing Stock Solutions for Cucurbitacin I

The following data is based on the product molecular weight 514.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.43 mL 97.15 mL 194.31 mL
0.5 mM 3.89 mL 19.43 mL 38.86 mL
1 mM 1.94 mL 9.72 mL 19.43 mL
5 mM 0.39 mL 1.94 mL 3.89 mL

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Product Datasheets for Cucurbitacin I

Certificate of Analysis / Product Datasheet
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8 Citations for Cucurbitacin I

Citations are publications that use Tocris products. Selected citations for Cucurbitacin I include:

Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. Cell Rep 10 e0143319 PMID: 26619345

Zhu et al (2016) Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene 35 5388 PMID: 27109105

Hamilton et al (2011) Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells. Mol Cancer Res 9 1718 PMID: 21994466

Tiffon et al (2011) The histone deacetylase inhibitors vorin. and romid. downmodulate IL-10 expression in cutaneous T-cell lymphoma cells. Br J Pharmacol 162 1590 PMID: 21198545

Do you know of a great paper that uses Cucurbitacin I from Tocris? Please let us know.

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Pathways for Cucurbitacin I

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.