Pricing Availability Delivery Time Qty
Cat.No. 2483 - Costunolide | C15H20O2 | CAS No. 553-21-9
Description: Inhibitor of human telomerase activity
Chemical Name: (3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one
Purity: ≥97% (HPLC)
Citations (2)

Biological Activity

Inhibitor of human telomerase activity (IC50 = 65 μM in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1β and disrupts NF-κB activation. Displays anti-inflammatory, antifungal and antiviral properties.

Technical Data

M. Wt 232.32
Formula C15H20O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 553-21-9
PubChem ID 5281437
Smiles C/C1=C\[C@@H](OC([C@]2=C)=O)[C@H]2CC/C(C)=C/CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.62 50
ethanol 11.62 50

Preparing Stock Solutions

The following data is based on the product molecular weight 232.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.3 mL 21.52 mL 43.04 mL
5 mM 0.86 mL 4.3 mL 8.61 mL
10 mM 0.43 mL 2.15 mL 4.3 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the products' biological activity.

Park et al (1996) Syringin 4-O-β-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldi. J.Nat.Prod. 59 1128 PMID: 8988596

Jeong et al (2002) Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. Cancer Lett. 187 129 PMID: 12359360

Choi et al (2005) Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells. Cancer Lett. 227 153 PMID: 16112418

If you know of a relevant reference for Costunolide, please let us know.

View Related Products by Product Action

View all Telomerase Inhibitors

Keywords: Costunolide, supplier, inhibitors, inhibits, human, telomerase, activity, Polymerases, Protein, Synthesis, RNA, DNA, Telomerase, DNA,, RNA, and, Protein, Synthesis, Antivirals, Telomerase, Tocris Bioscience

2 Citations for Costunolide

Citations are publications that use Tocris products. Selected citations for Costunolide include:

Ramirez et al (2013) Biosynthesis of sesquiterpene lactones in pyrethrum (Tanacetum cinerariifolium). PLoS One 8 e65030 PMID: 23741445

Liu et al (2011) Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. Neuron 6 e23255 PMID: 21858047

Do you know of a great paper that uses Costunolide from Tocris? If so please let us know.

Reviews for Costunolide

There are currently no reviews for this product. Be the first to review Costunolide and earn rewards!

Have you used Costunolide?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis