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Cat.No. 2483 - Costunolide | C15H20O2 | CAS No. 553-21-9
Description: Inhibitor of human telomerase activity
Chemical Name: (3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one
Purity: ≥97% (HPLC)
Citations (5)
Literature (1)

Biological Activity for Costunolide

Costunolide is an inhibitor of human telomerase activity (IC50 = 65 μM in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1β and disrupts NF-κB activation. Displays anti-inflammatory, antifungal and antiviral properties.

Technical Data for Costunolide

M. Wt 232.32
Formula C15H20O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 553-21-9
PubChem ID 5281437
Smiles C/C1=C\[C@@H](OC([C@]2=C)=O)[C@H]2CC/C(C)=C/CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Costunolide

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.62 50
ethanol 11.62 50

Preparing Stock Solutions for Costunolide

The following data is based on the product molecular weight 232.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.61 mL 43.04 mL 86.09 mL
2.5 mM 1.72 mL 8.61 mL 17.22 mL
5 mM 0.86 mL 4.3 mL 8.61 mL
25 mM 0.17 mL 0.86 mL 1.72 mL

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Product Datasheets for Costunolide

Certificate of Analysis / Product Datasheet
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References for Costunolide

References are publications that support the biological activity of the product.

Park et al (1996) Syringin 4-O-β-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldi. J.Nat.Prod. 59 1128 PMID: 8988596

Jeong et al (2002) Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. Cancer Lett. 187 129 PMID: 12359360

Choi et al (2005) Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells. Cancer Lett. 227 153 PMID: 16112418

If you know of a relevant reference for Costunolide, please let us know.

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Keywords: Costunolide, Costunolide supplier, inhibitors, inhibits, human, telomerase, activity, Polymerases, Protein, Synthesis, RNA, DNA, Telomerase, DNA,, and, Non-selective, Antivirals, 2483, Tocris Bioscience

5 Citations for Costunolide

Citations are publications that use Tocris products. Selected citations for Costunolide include:

Liu et al (2018) Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity. Nat Commun 9 4657 PMID: 30405138

Ramirez et al (2013) Biosynthesis of sesquiterpene lactones in pyrethrum (Tanacetum cinerariifolium). PLoS One 8 e65030 PMID: 23741445

Ahmad et al (2016) Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma. Cell Death Dis 7 e2213 PMID: 27148686

Liu et al (2011) Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. Neuron 6 e23255 PMID: 21858047

Do you know of a great paper that uses Costunolide from Tocris? Please let us know.

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Literature in this Area

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Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis