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Inhibitor of human telomerase activity (IC50 = 65 μM in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1β and disrupts NF-κB activation. Displays anti-inflammatory, antifungal and antiviral properties.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 232.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||8.61 mL||43.04 mL||86.09 mL|
|2.5 mM||1.72 mL||8.61 mL||17.22 mL|
|5 mM||0.86 mL||4.3 mL||8.61 mL|
|25 mM||0.17 mL||0.86 mL||1.72 mL|
References are publications that support the biological activity of the product.
Park et al (1996) Syringin 4-O-β-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldi. J.Nat.Prod. 59 1128 PMID: 8988596
Jeong et al (2002) Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. Cancer Lett. 187 129 PMID: 12359360
Choi et al (2005) Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells. Cancer Lett. 227 153 PMID: 16112418
If you know of a relevant reference for Costunolide, please let us know.
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Keywords: Costunolide, Costunolide supplier, inhibitors, inhibits, human, telomerase, activity, Polymerases, Protein, Synthesis, RNA, DNA, Telomerase, DNA,, and, Antivirals, 2483, Tocris Bioscience
5 Citations for Costunolide
Citations are publications that use Tocris products. Selected citations for Costunolide include:
Ahmad et al (2017) Telomerase reverse transcriptase (TERT) - enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA damage responses in glioblastoma. J Neurochem 143 671 PMID: 28833137
Liu et al (2011) Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. Neuron 6 e23255 PMID: 21858047
Liu et al (2018) Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity. Nat Commun 9 4657 PMID: 30405138
Ahmad et al (2016) Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma. Cell Death Dis 7 e2213 PMID: 27148686
Ramirez et al (2013) Biosynthesis of sesquiterpene lactones in pyrethrum (Tanacetum cinerariifolium). PLoS One 8 e65030 PMID: 23741445
Do you know of a great paper that uses Costunolide from Tocris? Please let us know.
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Literature in this Area
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