Inhibitor of human telomerase activity (IC50 = 65 μM in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1β and disrupts NF-κB activation. Displays anti-inflammatory, antifungal and antiviral properties.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 232.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.3 mL||21.52 mL||43.04 mL|
|5 mM||0.86 mL||4.3 mL||8.61 mL|
|10 mM||0.43 mL||2.15 mL||4.3 mL|
|50 mM||0.09 mL||0.43 mL||0.86 mL|
References are publications that support the biological activity of the product.
Park et al (1996) Syringin 4-O-β-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldi. J.Nat.Prod. 59 1128 PMID: 8988596
Jeong et al (2002) Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. Cancer Lett. 187 129 PMID: 12359360
Choi et al (2005) Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells. Cancer Lett. 227 153 PMID: 16112418
If you know of a relevant reference for Costunolide, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Costunolide, Costunolide supplier, inhibitors, inhibits, human, telomerase, activity, Polymerases, Protein, Synthesis, RNA, DNA, Telomerase, DNA,, and, Antivirals, 2483, Tocris Bioscience
3 Citations for Costunolide
Citations are publications that use Tocris products. Selected citations for Costunolide include:
Liu et al (2011) Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. Neuron 6 e23255 PMID: 21858047
Ahmad et al (2016) Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma. Cell Death Dis 7 e2213 PMID: 27148686
Ramirez et al (2013) Biosynthesis of sesquiterpene lactones in pyrethrum (Tanacetum cinerariifolium). PLoS One 8 e65030 PMID: 23741445
Do you know of a great paper that uses Costunolide from Tocris? Please let us know.
Reviews for Costunolide
There are currently no reviews for this product. Be the first to review Costunolide and earn rewards!
Have you used Costunolide?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.