Compound W

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Cat.No. 2654 - Compound W | C19H12N2O8 | CAS No. 173550-33-9
Description: γ-secretase inhibitor
Alternative Names: CW
Chemical Name: 3,5-Bis(4-nitrophenoxy)benzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Inhibitor of γ-secretase; causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).

Technical Data

M. Wt 396.31
Formula C19H12N2O8
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 173550-33-9
PubChem ID 16760376
InChI Key JOSXKPZXMVHRKU-UHFFFAOYSA-N
Smiles OC(=O)C1=CC(OC2=CC=C(C=C2)[N+]([O-])=O)=CC(OC2=CC=C(C=C2)[N+]([O-])=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 19.81 50
DMSO 39.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 396.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.62 mL 25.23 mL
5 mM 0.5 mL 2.52 mL 5.05 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Okochi et al (2006) Secretion of the notch-1 Aβ-like peptide during notch signaling. J.Biol.Chem. 281 7890 PMID: 16434391


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View all γ-Secretase Inhibitors

Keywords: Compound W, supplier, γ-secretase, gamma-secretase, inhibitors, inhibits, reduces, Aβ4, β42, beta42, levels, Proteinases, Proteases, β-Amyloid, beta-Amyloid, b-amyloid, Precursor, Protein, APP, beta, Peptides, CompoundW, amyloidbeta, amyloidb, amyloidβ, CW, Gamma-Secretase, Amyloid, Beta, Peptides, Gamma-Secretase, Tocris Bioscience

1 Citation for Compound W

Citations are publications that use Tocris products. Selected citations for Compound W include:

Greife et al (2014) Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer 14 628 PMID: 25167871


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