Combretastatin A4

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Cat.No. 1495 - Combretastatin A4 | C18H20O5 | CAS No. 117048-59-6
Description: Antiangiogenic
Alternative Names: CRC 87-09, NSC 817373
Chemical Name: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
Purity: ≥99%
Citations (2)
Literature (2)

Biological Activity

Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Inhibits tubulin polymerization.

Technical Data

M. Wt 316.35
Formula C18H20O5
Storage Desiccate at -20°C
Purity ≥99%
CAS Number 117048-59-6
PubChem ID 5351344
Smiles OC1=CC(\C=C/C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 31.64 100
DMSO 31.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 316.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.81 mL 31.61 mL
5 mM 0.63 mL 3.16 mL 6.32 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Dorr et al (1996) Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor. Invest.New Drugs 14 131 PMID: 8913833

Griggs et al (2001) Potent anti-metastatic activity of combretastatin-A4. Int.J.Oncol. 19 821 PMID: 11562761

Lin et al (2007) Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells. J.Pharmacol.Exp.Ther. 323 365 PMID: 17646428

If you know of a relevant reference for Combretastatin A4, please let us know.

Keywords: Combretastatin A4, Combretastatin A4 supplier, inhibitors, inhibits, tubulin, polymerization, Antitumor, antimetastatic, Antiangiogenics, Tau, Microtubules, Mitosis, CombretastatinA4, CRC87-09, NSC817373, CRC, 87-09, NSC, 817373, 1495, Tocris Bioscience

2 Citations for Combretastatin A4

Citations are publications that use Tocris products. Selected citations for Combretastatin A4 include:

Arora et al (2009) Novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity. J Biol Chem 69 1910 PMID: 19223556

Meseke et al (2018) Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin. Eneuro 5 PMID: 30406178

Do you know of a great paper that uses Combretastatin A4 from Tocris? Please let us know.

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Literature in this Area

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.