Combretastatin A4

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Cat.No. 1495 - Combretastatin A4 | C18H20O5 | CAS No. 117048-59-6
Description: Antiangiogenic
Alternative Names: CRC 87-09, NSC 817373
Chemical Name: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
Purity: ≥99%
Datasheet
Citations (1)
Literature

Biological Activity

Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Inhibits tubulin polymerization.

Technical Data

M. Wt 316.35
Formula C18H20O5
Storage Desiccate at -20°C
Purity ≥99%
CAS Number 117048-59-6
PubChem ID 5351344
InChI Key HVXBOLULGPECHP-WAYWQWQTSA-N
Smiles OC1=CC(\C=C/C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.64 100
ethanol 31.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 316.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.81 mL 31.61 mL
5 mM 0.63 mL 3.16 mL 6.32 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Dorr et al (1996) Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor. Invest.New Drugs 14 131 PMID: 8913833

Griggs et al (2001) Potent anti-metastatic activity of combretastatin-A4. Int.J.Oncol. 19 821 PMID: 11562761

Lin et al (2007) Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells. J.Pharmacol.Exp.Ther. 323 365 PMID: 17646428


If you know of a relevant reference for Combretastatin A4, please let us know.

Keywords: Combretastatin A4, supplier, inhibitors, inhibits, tubulin, polymerization, Antitumor, antimetastatic, Antiangiogenics, Tau, Microtubules, Mitosis, CombretastatinA4, CRC87-09, NSC817373, CRC, 87-09, NSC, 817373, Microtubules, Mitosis, Antiangiogenics, Antiangiogenics, Tocris Bioscience

1 Citation for Combretastatin A4

Citations are publications that use Tocris products. Selected citations for Combretastatin A4 include:

Arora et al (2009) Novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity. J Biol Chem 69 1910 PMID: 19223556


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