Combretastatin A4

Discontinued Product

Combretastatin A4 (Cat. No. 1495) has been withdrawn from sale for commercial reasons.
Cat.No. 1495 - Combretastatin A4 | C18H20O5 | CAS No. 117048-59-6
Description: Antiangiogenic
Alternative Names: CRC 87-09, NSC 817373
Chemical Name: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
Purity: ≥99%
Datasheet
Citations (2)
Reviews
Literature (2)

Biological Activity for Combretastatin A4

Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Inhibits tubulin polymerization.

Technical Data for Combretastatin A4

M. Wt 316.35
Formula C18H20O5
Storage Desiccate at -20°C
Purity ≥99%
CAS Number 117048-59-6
PubChem ID 5351344
InChI Key HVXBOLULGPECHP-WAYWQWQTSA-N
Smiles OC1=CC(\C=C/C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Combretastatin A4

Certificate of Analysis / Product Datasheet
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References for Combretastatin A4

References are publications that support the biological activity of the product.

Dorr et al (1996) Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor. Invest.New Drugs 14 131 PMID: 8913833

Griggs et al (2001) Potent anti-metastatic activity of combretastatin-A4. Int.J.Oncol. 19 821 PMID: 11562761

Lin et al (2007) Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells. J.Pharmacol.Exp.Ther. 323 365 PMID: 17646428

Keywords: Combretastatin A4, Combretastatin A4 supplier, inhibitors, inhibits, tubulin, polymerization, Antitumor, antimetastatic, Antiangiogenics, Tau, Microtubules, Mitosis, CombretastatinA4, CRC87-09, NSC817373, CRC, 87-09, NSC, 817373, 1495, Tocris Bioscience

2 Citations for Combretastatin A4

Citations are publications that use Tocris products. Selected citations for Combretastatin A4 include:

Meseke et al (2018) Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin. Eneuro 5 PMID: 30406178

Arora et al (2009) Novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity. J Biol Chem 69 1910 PMID: 19223556


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Literature in this Area

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