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Discontinued ProductCombretastatin A4 (Cat. No. 1495) has been withdrawn from sale for commercial reasons.
Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Inhibits tubulin polymerization.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Dorr et al (1996) Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor. Invest.New Drugs 14 131 PMID: 8913833
Griggs et al (2001) Potent anti-metastatic activity of combretastatin-A4. Int.J.Oncol. 19 821 PMID: 11562761
Lin et al (2007) Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells. J.Pharmacol.Exp.Ther. 323 365 PMID: 17646428
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Keywords: Combretastatin A4, Combretastatin A4 supplier, inhibitors, inhibits, tubulin, polymerization, Antitumor, antimetastatic, Antiangiogenics, Tau, Microtubules, Mitosis, CombretastatinA4, CRC87-09, NSC817373, CRC, 87-09, NSC, 817373, 1495, Tocris Bioscience
2 Citations for Combretastatin A4
Citations are publications that use Tocris products. Selected citations for Combretastatin A4 include:
Arora et al (2009) Novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity. J Biol Chem 69 1910 PMID: 19223556
Meseke et al (2018) Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin. Eneuro 5 PMID: 30406178
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