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Submit ReviewCocaine hydrochloride
Description: Inhibitor of monoamine transporters
Chemical Name: 3β-Hydroxy-1αH,5αH-tropane-2β-carboxylic acid methyl ester benzoate hydrochloride
Purity: ≥99% (HPLC)
Biological Activity
Competitive inhibitor of monoamine neurotransmitter transporters. Inhibits dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters with Ki values are 267, 392 and 872 nM respectively. Psychostimulant.
Technical Data
| M. Wt | 339.81 |
| Formula | C17H21NO4.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 53-21-4 |
| PubChem ID | 656832 |
| InChI Key | PIQVDUKEQYOJNR-VZXSFKIWSA-N |
| Smiles | O=C(C3=CC=CC=C3)O[C@@H]2[C@H]([C@](OC)=O)[C@@]1([H])CC[C@](C2)([H])N1C.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.98 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 339.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.94 mL | 14.71 mL | 29.43 mL |
| 5 mM | 0.59 mL | 2.94 mL | 5.89 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.94 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
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References
References are publications that support the biological activity of the product.
Fleckenstein et al (2000) Differential effects of stimulants on monoaminergic transporters: pharmacological consequences and implications for neurotoxicity. Eur.J.Pharmacol. 406 1 PMID: 11011026
Torres et al (2003) Plasma membrane monoamine transporters: structure, regulation and function. Nat.Rev.Neurosci. 4 13 PMID: 12511858
If you know of a relevant reference for Cocaine hydrochloride, please let us know.
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Keywords: Cocaine hydrochloride, Cocaine hydrochloride supplier, inhibitors, inhibits, monoamine, transporters, noradrenalin, noradrenaline, NET, adrenergic, neurotransmitter, DAT, dopamine, serotonin, SERT, 5-HT, reuptake, 5-Hydroxytryptamine, Dopamine, Transporters, Adrenergic, 2833, Tocris Bioscience
3 Citations for Cocaine hydrochloride
Citations are publications that use Tocris products. Selected citations for Cocaine hydrochloride include:
Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788
Ferraro et al (2012) A novel mechanism of cocaine to enhance DA d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology 37 1856 PMID: 22453136
Luu and Malenka (2008) Spike timing-dependent long-term potentiation in ventral tegmental area DA cells requires PKC. J Neurophysiol 100 533 PMID: 18450581
Do you know of a great paper that uses Cocaine hydrochloride from Tocris? Please let us know.
Reviews for Cocaine hydrochloride
Average Rating: 5 (Based on 1 Review.)
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Chronic restraint stress during withdrawal increases vulnerability to drug priming-induced cocaine seeking.
By
Kevin Ball on 01/28/2019
Assay Type: In Vivo
Species: Rat
We tested the effect of chronic restraint stress on cocaine seeking in rats using both extinction- and abstinence-based animal relapse models. Rats were trained to press a lever for I.V. cocaine infusions (0.50 mg/kg/infusion) paired with a discrete tone+light cue in daily 3-h sessions. A main finding was that a history of chronic restraint stress was associated with increased cocaine priming-induced drug seeking.
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