Cocaine hydrochloride

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Cat.No. 2833 - Cocaine hydrochloride | C17H21NO4.HCl | CAS No. 53-21-4
Description: Inhibitor of monoamine transporters
Chemical Name: 3β-Hydroxy-1αH,5αH-tropane-2β-carboxylic acid methyl ester benzoate hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Competitive inhibitor of monoamine neurotransmitter transporters. Inhibits dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters with Ki values are 267, 392 and 872 nM respectively. Psychostimulant.

Technical Data

M. Wt 339.81
Formula C17H21NO4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 53-21-4
PubChem ID 656832
InChI Key PIQVDUKEQYOJNR-VZXSFKIWSA-N
Smiles O=C(C3=CC=CC=C3)O[C@@H]2[C@H]([C@](OC)=O)[C@@]1([H])CC[C@](C2)([H])N1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 33.98 100

Preparing Stock Solutions

The following data is based on the product molecular weight 339.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.71 mL 29.43 mL
5 mM 0.59 mL 2.94 mL 5.89 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Fleckenstein et al (2000) Differential effects of stimulants on monoaminergic transporters: pharmacological consequences and implications for neurotoxicity. Eur.J.Pharmacol. 406 1 PMID: 11011026

Torres et al (2003) Plasma membrane monoamine transporters: structure, regulation and function. Nat.Rev.Neurosci. 4 13 PMID: 12511858


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View Related Products by Product Action

View all Dopamine Transporter Inhibitors

Keywords: inhibitors inhibits monoamine transporters noradrenalin noradrenaline transporters NET adrenergic monoamine neurotransmitter DAT dopamine serotonin SERT 5-HT reuptake 5-Hydroxytryptamine Dopamine Transporters

1 Citation for Cocaine hydrochloride

Citations are publications that use Tocris products. Selected citations for Cocaine hydrochloride include:

Ferraro et al (2012) A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology 37 1856 PMID: 22453136


Do you know of a great paper that uses Cocaine hydrochloride from Tocris? If so please let us know.

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Literature in this Area

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Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

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Pathways for Cocaine hydrochloride

Protocols

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