Cocaine hydrochloride
Biological Activity
Competitive inhibitor of monoamine neurotransmitter transporters. Inhibits dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters with Ki values are 267, 392 and 872 nM respectively. Psychostimulant.
Technical Data
| M. Wt | 339.81 |
| Formula | C17H21NO4.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 53-21-4 |
| PubChem ID | 656832 |
| InChI Key | PIQVDUKEQYOJNR-VZXSFKIWSA-N |
| Smiles | O=C(C3=CC=CC=C3)O[C@@H]2[C@H]([C@](OC)=O)[C@@]1([H])CC[C@](C2)([H])N1C.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.98 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 339.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.94 mL | 14.71 mL | 29.43 mL |
| 5 mM | 0.59 mL | 2.94 mL | 5.89 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.94 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
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References
References are publications that support the biological activity of the product.
Fleckenstein et al (2000) Differential effects of stimulants on monoaminergic transporters: pharmacological consequences and implications for neurotoxicity. Eur.J.Pharmacol. 406 1 PMID: 11011026
Torres et al (2003) Plasma membrane monoamine transporters: structure, regulation and function. Nat.Rev.Neurosci. 4 13 PMID: 12511858
If you know of a relevant reference for Cocaine hydrochloride, please let us know.
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3 Citations for Cocaine hydrochloride
Citations are publications that use Tocris products. Selected citations for Cocaine hydrochloride include:
Luu and Malenka (2008) Spike timing-dependent long-term potentiation in ventral tegmental area dopamine cells requires PKC. J Neurophysiol 100 533 PMID: 18450581
Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788
Ferraro et al (2012) A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology 37 1856 PMID: 22453136
Do you know of a great paper that uses Cocaine hydrochloride from Tocris? Please let us know.
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