CL 218872

Pricing Availability   Qty
Description: Benzodiazepine agonist
Chemical Name: 3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (7)

Biological Activity for CL 218872

CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.

Technical Data for CL 218872

M. Wt 278.24
Formula C13H9F3N4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 66548-69-4
PubChem ID 107950
InChI Key GUOQUXNJZHGPQF-UHFFFAOYSA-N
Smiles CC1=NN=C2C=CC(=NN12)C1=CC(=CC=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CL 218872

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.91 50
ethanol 6.96 25

Preparing Stock Solutions for CL 218872

The following data is based on the product molecular weight 278.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.19 mL 35.94 mL 71.88 mL
2.5 mM 1.44 mL 7.19 mL 14.38 mL
5 mM 0.72 mL 3.59 mL 7.19 mL
25 mM 0.14 mL 0.72 mL 1.44 mL

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Product Datasheets for CL 218872

Certificate of Analysis / Product Datasheet
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References for CL 218872

References are publications that support the biological activity of the product.

Lippa et al (1979) Benzodiazepine receptors: cellular and behavioral characteristics. Pharmacol.Biochem.Behav. 10 831 PMID: 40258

Sieghart (1995) Structure and pharmacology of γ-aminobutyric acidA receptor subtypes. Pharmacol.Rev. 47 181 PMID: 7568326

Squires et al (1979) Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol.Biochem.Behav. 10 825 PMID: 40257


If you know of a relevant reference for CL 218872, please let us know.

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Keywords: CL 218872, CL 218872 supplier, Benzodiazepine, agonists, GABAA, Receptors, CL218872, 1709, Tocris Bioscience

1 Citation for CL 218872

Citations are publications that use Tocris products. Selected citations for CL 218872 include:

Wang et al (2018) Contribution of the α5 GABAA receptor to the discriminative stimulus effects of PROP in rat. Neuroreport 29 347 PMID: 29369902


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Reviews for CL 218872

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

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