CL 218872

Discontinued Product

CL 218872 (Cat. No. 1709) has been withdrawn from sale for commercial reasons.
Description: Benzodiazepine agonist
Chemical Name: 3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for CL 218872

CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.

Technical Data for CL 218872

M. Wt 278.24
Formula C13H9F3N4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 66548-69-4
PubChem ID 107950
Smiles CC1=NN=C2C=CC(=NN12)C1=CC(=CC=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for CL 218872

Certificate of Analysis / Product Datasheet
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References for CL 218872

References are publications that support the biological activity of the product.

Lippa et al (1979) Benzodiazepine receptors: cellular and behavioral characteristics. Pharmacol.Biochem.Behav. 10 831 PMID: 40258

Sieghart (1995) Structure and pharmacology of γ-aminobutyric acidA receptor subtypes. Pharmacol.Rev. 47 181 PMID: 7568326

Squires et al (1979) Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol.Biochem.Behav. 10 825 PMID: 40257

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Keywords: CL 218872, CL 218872 supplier, Benzodiazepine, agonists, GABAA, Receptors, CL218872, 1709, Tocris Bioscience

1 Citation for CL 218872

Citations are publications that use Tocris products. Selected citations for CL 218872 include:

Wang et al (2018) Contribution of the α5 GABAA receptor to the discriminative stimulus effects of PROP in rat. Neuroreport 29 347 PMID: 29369902

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.