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Submit ReviewCL 218872
Description: Benzodiazepine agonist
Chemical Name: 3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine
Purity: ≥98% (HPLC)
Biological Activity for CL 218872
CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.
Technical Data for CL 218872
| M. Wt | 278.24 |
| Formula | C13H9F3N4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 66548-69-4 |
| PubChem ID | 107950 |
| InChI Key | GUOQUXNJZHGPQF-UHFFFAOYSA-N |
| Smiles | CC1=NN=C2C=CC(=NN12)C1=CC(=CC=C1)C(F)(F)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CL 218872
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.91 | 50 | |
| ethanol | 6.96 | 25 |
Preparing Stock Solutions for CL 218872
The following data is based on the product molecular weight 278.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 7.19 mL | 35.94 mL | 71.88 mL |
| 2.5 mM | 1.44 mL | 7.19 mL | 14.38 mL |
| 5 mM | 0.72 mL | 3.59 mL | 7.19 mL |
| 25 mM | 0.14 mL | 0.72 mL | 1.44 mL |
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Product Datasheets for CL 218872
References for CL 218872
References are publications that support the biological activity of the product.
Lippa et al (1979) Benzodiazepine receptors: cellular and behavioral characteristics. Pharmacol.Biochem.Behav. 10 831 PMID: 40258
Sieghart (1995) Structure and pharmacology of γ-aminobutyric acidA receptor subtypes. Pharmacol.Rev. 47 181 PMID: 7568326
Squires et al (1979) Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol.Biochem.Behav. 10 825 PMID: 40257
If you know of a relevant reference for CL 218872, please let us know.
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Keywords: CL 218872, CL 218872 supplier, Benzodiazepine, agonists, GABAA, Receptors, CL218872, 1709, Tocris Bioscience
1 Citation for CL 218872
Citations are publications that use Tocris products. Selected citations for CL 218872 include:
Wang et al (2018) Contribution of the α5 GABAA receptor to the discriminative stimulus effects of PROP in rat. Neuroreport 29 347 PMID: 29369902
Do you know of a great paper that uses CL 218872 from Tocris? Please let us know.
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