CL 218872

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Cat.No. 1709 - CL 218872 | C13H9F3N4 | CAS No. 66548-69-4
Description: Benzodiazepine agonist
Chemical Name: 3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.

Compound Libraries

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Technical Data

M. Wt 278.24
Formula C13H9F3N4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 66548-69-4
PubChem ID 107950
InChI Key GUOQUXNJZHGPQF-UHFFFAOYSA-N
Smiles CC1=NN=C2C=CC(=NN12)C1=CC(=CC=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 6.96 25
DMSO 13.91 50

Preparing Stock Solutions

The following data is based on the product molecular weight 278.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.19 mL 35.94 mL 71.88 mL
2.5 mM 1.44 mL 7.19 mL 14.38 mL
5 mM 0.72 mL 3.59 mL 7.19 mL
25 mM 0.14 mL 0.72 mL 1.44 mL

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References

References are publications that support the biological activity of the product.

Lippa et al (1979) Benzodiazepine receptors: cellular and behavioral characteristics. Pharmacol.Biochem.Behav. 10 831 PMID: 40258

Sieghart (1995) Structure and pharmacology of γ-aminobutyric acidA receptor subtypes. Pharmacol.Rev. 47 181 PMID: 7568326

Squires et al (1979) Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol.Biochem.Behav. 10 825 PMID: 40257


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Keywords: CL 218872, CL 218872 supplier, Benzodiazepine, agonists, GABAA, Receptors, CL218872, 1709, Tocris Bioscience

Citations for CL 218872

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*Please note that Tocris will only send literature to established scientific business / institute addresses.


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