Benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 278.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.59 mL||17.97 mL||35.94 mL|
|5 mM||0.72 mL||3.59 mL||7.19 mL|
|10 mM||0.36 mL||1.8 mL||3.59 mL|
|50 mM||0.07 mL||0.36 mL||0.72 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Lippa et al (1979) Benzodiazepine receptors: cellular and behavioral characteristics. Pharmacol.Biochem.Behav. 10 831 PMID: 40258
Sieghart (1995) Structure and pharmacology of γ-aminobutyric acidA receptor subtypes. Pharmacol.Rev. 47 181 PMID: 7568326
Squires et al (1979) Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol.Biochem.Behav. 10 825 PMID: 40257
If you know of a relevant reference for CL 218872, please let us know.
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Keywords: CL 218872, supplier, Benzodiazepine, agonists, GABAA, Receptors, CL218872, GABAA, Receptors, Tocris Bioscience
Citations for CL 218872
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