Chlormethiazole hydrochloride

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Cat.No. 0881 - Chlormethiazole hydrochloride | C6H8ClNS.HCl | CAS No. 6001-74-7
Description: Potentiates GABAA receptor function
Chemical Name: 5-(2-Chloroethyl)-4-methylthiazole hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Sedative and anticonvulsant which is neuroprotective in a number of animal models. Prevents the degeneration of serotonergic nerve terminals induced by MDMA ('Ecstasy').

Technical Data

M. Wt 198.11
Formula C6H8ClNS.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 6001-74-7
PubChem ID 19035073
InChI Key OFXYKSLKNMTBHK-UHFFFAOYSA-N
Smiles ClCCC1=C(C)N=CS1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.81 100

Preparing Stock Solutions

The following data is based on the product molecular weight 198.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.05 mL 25.24 mL 50.48 mL
5 mM 1.01 mL 5.05 mL 10.1 mL
10 mM 0.5 mL 2.52 mL 5.05 mL
50 mM 0.1 mL 0.5 mL 1.01 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Cross et al (1995) The protective action of chloromethiazole against ischaemia induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity. Br.J.Pharmacol. 114 1625 PMID: 7599932

Hewitt and Green (1994) Chloromethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by the administration of MDMA ('Ecstasy') to rats. Neuropharmacology 33 1589 PMID: 7539115


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