Sedative and anticonvulsant which is neuroprotective in a number of animal models. Prevents the degeneration of serotonergic nerve terminals induced by MDMA ('Ecstasy').
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 198.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.05 mL||25.24 mL||50.48 mL|
|5 mM||1.01 mL||5.05 mL||10.1 mL|
|10 mM||0.5 mL||2.52 mL||5.05 mL|
|50 mM||0.1 mL||0.5 mL||1.01 mL|
References are publications that support the products' biological activity.
Cross et al (1995) The protective action of chloromethiazole against ischaemia induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity. Br.J.Pharmacol. 114 1625 PMID: 7599932
Hewitt and Green (1994) Chloromethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by the administration of MDMA ('Ecstasy') to rats. Neuropharmacology 33 1589 PMID: 7539115
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Keywords: Chlormethiazole hydrochloride, supplier, Potentiates, GABAA, receptor, function, Receptors, modulators, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
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