Chlormethiazole hydrochloride

Discontinued Product

Chlormethiazole hydrochloride (Cat. No. 0881) has been withdrawn from sale for commercial reasons.
Description: Potentiates GABAA receptor function
Chemical Name: 5-(2-Chloroethyl)-4-methylthiazole hydrochloride
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for Chlormethiazole hydrochloride

Chlormethiazole hydrochloride is a sedative and anticonvulsant which is neuroprotective in a number of animal models. Prevents the degeneration of serotonergic nerve terminals induced by MDMA ('Ecstasy').

Technical Data for Chlormethiazole hydrochloride

M. Wt 198.11
Formula C6H8ClNS.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 6001-74-7
PubChem ID 19035073
Smiles ClCCC1=C(C)N=CS1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Chlormethiazole hydrochloride

Certificate of Analysis / Product Datasheet
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References for Chlormethiazole hydrochloride

References are publications that support the biological activity of the product.

Cross et al (1995) The protective action of chloromethiazole against ischaemia induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity. Br.J.Pharmacol. 114 1625 PMID: 7599932

Hewitt and Green (1994) Chloromethiazole, dizocilpine and halope. prevent the degeneration of serotonergic nerve terminals induced by the administration of MDMA ('Ecstasy') to rats. Neuropharmacology 33 1589 PMID: 7539115

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Citations for Chlormethiazole hydrochloride

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Currently there are no citations for Chlormethiazole hydrochloride.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.