CHDI 113

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Description: Potent HTT pre-RNA splicing modulator
Chemical Name: 5-[(3R)-3-(Cyclopropylamino)-1-pyrrolidinyl]-N-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-2-pyrazinecarboxamide
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for CHDI 113

CHDI 113 is a potent huntingtin (HTT) pre-mRNA splicing modulator (EC50 = 66 nM). It lowers HTT protein in both human Huntington's disease (HD) stem cells and in the brain of BACHD (bacterial artificial chromosome-mediated transgenic) mouse model. CHDI 113 is brain penetrant and orally bioavailable.

Licensing Information

Sold under license from CHDI Foundation

Technical Data for CHDI 113

M. Wt 395.44
Formula C20H22FN7O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2743336-70-9
PubChem ID 166508076
Smiles FC1=CC(NC(C2=NC=C(N3C[C@@H](CC3)NC4CC4)N=C2)=O)=CN5C1=NC(C)=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CHDI 113

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.54 100

Preparing Stock Solutions for CHDI 113

The following data is based on the product molecular weight 395.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References for CHDI 113

References are publications that support the biological activity of the product.

Liu et al (2023) Identification and optimization of RNA-splicing modulators as Huntingtin protein-lowering agents for the treatment of Huntington's disease. J.Med.Chem. 66 13205 PMID: 37712656

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1 Citation for CHDI 113

Citations are publications that use Tocris products. Selected citations for CHDI 113 include:

Liu et al (2024) Identification and optimization of RNA-splicing modulators as Huntingtin protein-lowering agents for the treatment of Huntington's disease. J.Med.Chem. 66 13205 PMID: 37712656

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
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  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
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Huntington's Disease Research Product Guide

Huntington's Disease Research Product Guide

This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:

  • Somatic Instability
  • Proteolysis and Inclusion Bodies
  • Transcriptional Dysregulation
  • Mitochondrial Dysfunction
  • Nuclear-Cytoplasmic Transport Interference
  • Excitotoxicity
  • Stem Cells