cGMP Dependent Kinase Inhibitor Peptide

Pricing Availability Delivery Time Qty
Cat.No. 1883 - cGMP dependent kinase inhibitor peptide | Arg-Lys-Arg-Ala-Arg-Lys-Glu | CAS No. 82801-73-8
Description: Inhibitor of protein kinases G and A
Alternative Names: [Ala32]H2B(29-35)

Biological Activity

Competitive inhibitor of cGMP-dependent protein kinase (PKG); analog of a substrate peptide corresponding to a phosphorylation site of histone H2B. Competes with synthetic substrates (Ki = 86 mM) but does not inhibit phosphorylation of intact histones by PKG. Inhibits phosphorylation of intact histones by PKA.

Technical Data

M. Wt 943.12
Formula C38H74N18O10
Sequence RKRARKE
Storage Desiccate at -20°C
CAS Number 82801-73-8
PubChem ID 134097
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 943.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.06 mL 5.3 mL 10.6 mL
5 mM 0.21 mL 1.06 mL 2.12 mL
10 mM 0.11 mL 0.53 mL 1.06 mL
50 mM 0.02 mL 0.11 mL 0.21 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Bhatnagar et al (1988) Synthetic peptide analogues differentially alter the binding affinities of cyclic nucleotide dependent protein kinases for nucleotide substrates. Biochemistry 27 1988 PMID: 2837278

Glass (1983) Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitors. Biochem.J. 213 159 PMID: 6615418

Glass et al (1986) Differential and common recognition of the catalytic sites of the cGMP-dependent and cAMP-dependent protein kinases by inhibitory peptides derived from the heat-stable inhibitor protein. J.Biol.Chem. 261 12166 PMID: 3017964

If you know of a relevant reference for cGMP Dependent Kinase Inhibitor Peptide, please let us know.

View Related Products by Product Action

View all Protein Kinase A Inhibitors

Keywords: cGMP dependent kinase inhibitor peptide, supplier, inhibitors, inhibits, protein, kinases, A, G, PKA, PKG, [Ala32]H2B(29-35), Protein, Kinase, A, Protein, Kinase, G, Protein, Kinase, A, Tocris Bioscience

Citations for cGMP Dependent Kinase Inhibitor Peptide

Citations are publications that use Tocris products.

Currently there are no citations for cGMP Dependent Kinase Inhibitor Peptide. Do you know of a great paper that uses cGMP Dependent Kinase Inhibitor Peptide from Tocris? If so please let us know.

Reviews for cGMP dependent kinase inhibitor peptide

There are currently no reviews for this product. Be the first to review cGMP dependent kinase inhibitor peptide and earn rewards!

Have you used cGMP dependent kinase inhibitor peptide?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling