cGMP Dependent Kinase Inhibitor Peptide

Discontinued Product

cGMP Dependent Kinase Inhibitor Peptide (Cat. No. 1883) has been withdrawn from sale for commercial reasons.
Cat.No. 1883 - cGMP dependent kinase inhibitor peptide | Arg-Lys-Arg-Ala-Arg-Lys-Glu | CAS No. 82801-73-8
Description: Inhibitor of protein kinases G and A
Alternative Names: [Ala32]H2B(29-35)
Datasheet
Citations
Reviews (1)
Literature (3)

Biological Activity

cGMP Dependent Kinase Inhibitor Peptide is a competitive inhibitor of cGMP-dependent protein kinase (PKG); analog of a substrate peptide corresponding to a phosphorylation site of histone H2B. Competes with synthetic substrates (Ki = 86 mM) but does not inhibit phosphorylation of intact histones by PKG. Inhibits phosphorylation of intact histones by PKA.

Technical Data

M. Wt 943.12
Formula C38H74N18O10
Sequence RKRARKE
Storage Desiccate at -20°C
CAS Number 82801-73-8
PubChem ID 134097
InChI Key OUKSKNTVYYVIMZ-DUJSLOSMSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: cGMP dependent kinase inhibitor peptide, cGMP dependent kinase inhibitor peptide supplier, inhibitors, inhibits, protein, kinases, A, G, PKA, PKG, [Ala32]H2B(29-35), Protein, Kinase, 1883, Tocris Bioscience

Citations for cGMP Dependent Kinase Inhibitor Peptide

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Reviews for cGMP Dependent Kinase Inhibitor Peptide

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We examined the regulatory mechanism of the PKG holoenzymes.
By Anonymous on 02/26/2019
Species: Human

We examined the regulatory mechanism of the PKG holoenzymes. The development of cGMP-independent peptide activators of PKG I alpha, derived from this helical segment was found bridging the regulatory and catalytic domains.

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