CG 428-Neg

Pricing Availability   Qty
Cat.No. 7426 - CG 428-Neg | C44H45FN10O6
Description: Negative control for CG 428 (Cat. No. 7425)
Chemical Name: 2-(1-Methyl-2,6-dioxo-3-piperidinyl)-4-[[2-[3-[4-[6-[6-[(2R)-2-(3-fluorophenyl)-1-pyrrolidinyl]imidazo[1,2-b]pyridazin-3-yl]-2-pyridinyl]-1-piperazinyl]-3-oxopropoxy]ethyl]amino]-1H-isoindole-1,3(2H)-dione
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for CG 428-Neg

Negative control for CG 428 (Cat. No. 7425).

Licensing Information

Sold under license from Cullgen

Technical Data for CG 428-Neg

M. Wt 828.91
Formula C44H45FN10O6
Storage Store at -20°C
Purity ≥98% (HPLC)
Smiles FC1=CC=CC([C@H]2CCCN2C3=NN4C(C=C3)=NC=C4C5=NC(N6CCN(C(CCOCCNC7=C8C(N(C(C8=CC=C7)=O)C9CCC(N(C)C9=O)=O)=O)=O)CC6)=CC=C5)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CG 428-Neg

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 82.89 100

Preparing Stock Solutions for CG 428-Neg

The following data is based on the product molecular weight 828.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.21 mL 6.03 mL 12.06 mL
5 mM 0.24 mL 1.21 mL 2.41 mL
10 mM 0.12 mL 0.6 mL 1.21 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

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References for CG 428-Neg

References are publications that support the biological activity of the product.

Chen et al (2020) Discovery of first-in-class potent and selective tropomyosin receptor kinase degraders. J.Med.Chem. 63 14562 PMID: 33058680

If you know of a relevant reference for CG 428-Neg, please let us know.

Keywords: CG 428-Neg, CG 428-Neg supplier, CG428-Neg, negative, control, degraders, E3, ligase, uSMITE, kinases, TRK, tropomyosin, PROTAC, targeted, protein, degradation, Ubiquitin-mediated, Small, Molecule-Induced, Target, Elimination, Active, Degraders, Other, Kinases, 7426, Tocris Bioscience

Citations for CG 428-Neg

Citations are publications that use Tocris products.

Currently there are no citations for CG 428-Neg. Do you know of a great paper that uses CG 428-Neg from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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