Cercosporamide

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Cat.No. 4500 - Cercosporamide | C16H13NO7 | CAS No. 131436-22-1
Description: Potent Mnk2 inhibitor
Chemical Name: (9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancaboxamide
Purity: ≥96% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro. Also inhibits Pkc1. Orally bioavailable.

Technical Data

M. Wt 331.28
Formula C16H13NO7
Storage Store at -20°C
Purity ≥96% (HPLC)
CAS Number 131436-22-1
PubChem ID 131379
InChI Key GEWLYFZWVLXQME-MRXNPFEDSA-N
Smiles OC1=CC(O)=C(C(N)=O)C3=C1[C@@]2(C)C(O3)=CC(O)=C(C(C)=O)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.31 10

Preparing Stock Solutions

The following data is based on the product molecular weight 331.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.19 mL 150.93 mL 301.86 mL
0.5 mM 6.04 mL 30.19 mL 60.37 mL
1 mM 3.02 mL 15.09 mL 30.19 mL
5 mM 0.6 mL 3.02 mL 6.04 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Konicek et al (2011) Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. Cancer Res. 71 1849 PMID: 21233335

Hou et al (2012) Targeting Mnks for cancer therapy. Oncotarget 3 118 PMID: 22392765

Sussman et al (2004) Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Eukaryot.Cell 3 932 PMID: 15302826


If you know of a relevant reference for Cercosporamide, please let us know.

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Keywords: Cercosporamide, Cercosporamide supplier, antifungals, Mnk2, MKNK2, MAP-kinase, interacting, kinases, Jak3, inhibitors, inhibits, JAK, Kinase, Mnk, 4500, Tocris Bioscience

1 Citation for Cercosporamide

Citations are publications that use Tocris products. Selected citations for Cercosporamide include:

Westergard et al (2019) Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. EMBO Mol Med 11 PMID: 30617154


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.