Nrf2 signaling activator; increases Nrf2 protein expression and enhances Nrf2-dependent cytoprotective gene expression. Inhibits cell growth and induces apoptosis of pancreatic cancer cells in vitro. Also reduces acetaminophen-induced liver injury in mice.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 541.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.85 mL||9.23 mL||18.46 mL|
|5 mM||0.37 mL||1.85 mL||3.69 mL|
|10 mM||0.18 mL||0.92 mL||1.85 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
References are publications that support the biological activity of the product.
Reisman et al (2009) CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes. Toxicol.Appl.Pharmacol. 236 109 PMID: 19371629
Samudio et al (2005) 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. J.Biol.Chem. 280 36273 PMID: 16118208
Aleksunes et al (2010) Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity. J.Pharmacol.Exp.Ther. 335 2 PMID: 20605904
If you know of a relevant reference for CDDO Im, please let us know.
View Related Products by Product Action
Keywords: CDDO Im, CDDO Im supplier, CDDOIm, Nrf2, activators, NFE2L2, erythroid-derived, nuclear, factor, 4737, Tocris Bioscience
Citations for CDDO Im
Citations are publications that use Tocris products.
Currently there are no citations for CDDO Im. Do you know of a great paper that uses CDDO Im from Tocris? Please let us know.
Reviews for CDDO Im
There are currently no reviews for this product. Be the first to review CDDO Im and earn rewards!
Have you used CDDO Im?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.