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Synthetic retinoid that is an RARγ-selective agonist. Displays RARγ-dependent and -independent effects on differentiation and apoptosis.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 398.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.51 mL||12.55 mL||25.09 mL|
|5 mM||0.5 mL||2.51 mL||5.02 mL|
|10 mM||0.25 mL||1.25 mL||2.51 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
References are publications that support the biological activity of the product.
Zhao and Spanjaard (2003) The apoptotic action of the retinoid CD437/AHPN: diverse effects, common basis. J.Biomed.Sci. 10 44 PMID: 12566985
Wang et al (2011) Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1. Proc.Natl.Acad.Sci U.S.A. 108 18283 PMID: 21990348
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Keywords: CD 437, CD 437 supplier, RARγ, RARgamma-selective, agonists, RAR, RAMBA, Retinoic, Acid, Receptors, peroxisome, proliferator-activating, CD437, AHPN, 1549, Tocris Bioscience
4 Citations for CD 437
Citations are publications that use Tocris products. Selected citations for CD 437 include:
Lee et al (2017) Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations. Cell Stem Cell 21 179 PMID: 28777944
Brigger et al (2015) Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity. J Neurosci 6 e1861 PMID: 26313912
Huang et al (2019) Perturbational Gene-Expression Signatures for Combinatorial Drug Discovery. iScience 15 291 PMID: 31102995
Kelley (2017) Retinoic acid receptor gamma impacts cellular adhesion, Alpha5 Beta1 integrin expression and proliferation in K562 cells. PLoS One 12 e0178116 PMID: 28552962
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Literature in this Area
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