Synthetic retinoid that is an RARγ-selective agonist. Displays RARγ-dependent and -independent effects on differentiation and apoptosis.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 398.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.51 mL||12.55 mL||25.09 mL|
|5 mM||0.5 mL||2.51 mL||5.02 mL|
|10 mM||0.25 mL||1.25 mL||2.51 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Zhao and Spanjaard (2003) The apoptotic action of the retinoid CD437/AHPN: diverse effects, common basis. J.Biomed.Sci. 10 44 PMID: 12566985
Wang et al (2011) Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1. Proc.Natl.Acad.Sci U.S.A. 108 18283 PMID: 21990348
If you know of a relevant reference for CD 437, please let us know.
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Keywords: RARγ RARgamma-selective agonists RAR RAMBA Retinoic Acid Receptors peroxisome proliferator-activating CD437 AHPN Retinoic Acid Receptors
2 Citations for CD 437
Citations are publications that use Tocris products. Selected citations for CD 437 include:
Kelley (2017) Retinoic acid receptor gamma impacts cellular adhesion, Alpha5 Beta1 integrin expression and proliferation in K562 cells. PLoS One 12 e0178116 PMID: 28552962
Brigger et al (2015) Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity. J Neurosci 6 e1861 PMID: 26313912
Do you know of a great paper that uses CD 437 from Tocris? If so please let us know.