CD 437

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Cat.No. 1549 - CD 437 | C27H26O3 | CAS No. 125316-60-1
Description: RARγ-selective agonist
Alternative Names: AHPN
Chemical Name: 6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Synthetic retinoid that is an RARγ-selective agonist. Displays RARγ-dependent and -independent effects on differentiation and apoptosis.

Compound Libraries

CD 437 is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 398.5
Formula C27H26O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 125316-60-1
PubChem ID 135411
InChI Key LDGIHZJOIQSHPB-UHFFFAOYSA-N
Smiles OC(=O)C1=CC=C2C=C(C=CC2=C1)C1=CC=C(O)C(=C1)C12CC3CC(CC(C3)C1)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.85 100
ethanol 7.97 20

Preparing Stock Solutions

The following data is based on the product molecular weight 398.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.09 mL
5 mM 0.5 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Zhao and Spanjaard (2003) The apoptotic action of the retinoid CD437/AHPN: diverse effects, common basis. J.Biomed.Sci. 10 44 PMID: 12566985

Wang et al (2011) Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1. Proc.Natl.Acad.Sci U.S.A. 108 18283 PMID: 21990348


If you know of a relevant reference for CD 437, please let us know.

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View all Retinoic Acid Receptor Agonists

Keywords: RARγ RARgamma-selective agonists RAR RAMBA Retinoic Acid Receptors peroxisome proliferator-activating CD437 AHPN Retinoic Acid Receptors

2 Citations for CD 437

Citations are publications that use Tocris products. Selected citations for CD 437 include:

Kelley (2017) Retinoic acid receptor gamma impacts cellular adhesion, Alpha5 Beta1 integrin expression and proliferation in K562 cells. PLoS One 12 e0178116 PMID: 28552962

Brigger et al (2015) Activation of RARĪ± induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity. J Neurosci 6 e1861 PMID: 26313912


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Reviews

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Literature in this Area

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Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.

Pathways for CD 437

Protocols

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