CD 2665

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Description: Selective RARβ/γ antagonist
Chemical Name: 4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[,7]dec-1-yl-2-naphthalenyl)benzoic acid
Purity: ≥98% (HPLC)
Citations (10)
Literature (1)

Biological Activity for CD 2665

CD 2665 is a selective RARβγ antagonist (KD values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). Blocks retinoic acid-induced apoptosis ex vivo.

Compound Libraries for CD 2665

CD 2665 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CD 2665

M. Wt 486.6
Formula C31H34O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 170355-78-9
PubChem ID 216241
Smiles COCCOCOC(C(C3(CC5C4)CC(C5)CC4C3)=C2)=CC1=C2C=C(C6=CC=C(C(O)=O)C=C6)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CD 2665

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 48.66 100

Preparing Stock Solutions for CD 2665

The following data is based on the product molecular weight 486.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.06 mL 10.28 mL 20.55 mL
5 mM 0.41 mL 2.06 mL 4.11 mL
10 mM 0.21 mL 1.03 mL 2.06 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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Product Datasheets for CD 2665

Certificate of Analysis / Product Datasheet
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References for CD 2665

References are publications that support the biological activity of the product.

Szondy et al (1997) Induction of apoptosis by retinoids and retinoic acid receptor γ-selective compounds in mouse thymocytes through a novel apoptosis pathway. Mol.Pharmacol. 51 972 PMID: 9187263

Meister et al (1998) Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectivity binding retinoids in neuroblastoma. Anticancer Res. 18 1777 PMID: 9673404

Kim et al (2000) The role of specific retinoid receptors in sebocyte growth and differentiation in culture. J.Invest.Dermatol. 114 349 PMID: 10651997

If you know of a relevant reference for CD 2665, please let us know.

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View all Retinoic Acid Receptor Antagonists

Keywords: CD 2665, CD 2665 supplier, CD2665, selective, retinoic, acid, receptors, gamma, beta, RARgamma, RARbeta, RARb, RARg, RARγ, RAR#946;, antagonists, Retinoic, Acid, Receptors, 3800, Tocris Bioscience

10 Citations for CD 2665

Citations are publications that use Tocris products. Selected citations for CD 2665 include:

Mei et al (2023) IL-3 produced by T cells is crucial for basophil extravasation in hapten-induced allergic contact dermatitis. Front Immunol 14 1151468 PMID: 37180157

Martin et al (2014) Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid. Mucosal Immunol 7 101 PMID: 23653115

Ane et al (2021) Retinoic acid signaling is critical during the totipotency window in early mammalian development. Nat Struct Mol Biol 28 521-532 PMID: 34045724

Liang et al (2013) Retinoic acid inhibits CD25+ dendritic cell expansion and γδ T-cell activation in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 54 3493 PMID: 23611991

Do you know of a great paper that uses CD 2665 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.