CD 2314

Pricing Availability   Qty
Description: Selective RARβ agonist
Chemical Name: 5-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)-3-thiophenecarboxylic acid
Purity: ≥98% (HPLC)
Citations (5)
Literature (1)

Biological Activity for CD 2314

CD 2314 is a potent and selective RARβ receptor agonist (Kd values are 145 and >3760 nM for RARβ and RARα receptors respectively; no binding detected at RARγ). Inhibits growth of human HNSCC 22B, 183A and 22A cells (IC50 values are 3.0, 5.7 and 8.0 μM respectively).

Compound Libraries for CD 2314

CD 2314 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CD 2314

M. Wt 364.5
Formula C23H24O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 170355-37-0
PubChem ID 15293210
Smiles CC(CCC(C)4C)(C)C1=C4C=C(C=CC(C3=CC(C(O)=O)=CS3)=C2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CD 2314

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.45 100

Preparing Stock Solutions for CD 2314

The following data is based on the product molecular weight 364.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.43 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets for CD 2314

Certificate of Analysis / Product Datasheet
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Keywords: CD 2314, CD 2314 supplier, CD2314, Selective, RARβ, RARbeta, agonists, Retinoic, Acid, Receptors, 3824, Tocris Bioscience

5 Citations for CD 2314

Citations are publications that use Tocris products. Selected citations for CD 2314 include:

Chronopoulos et al (2016) ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion Nature Communications 7 12630 PMID: 27600527

Duprey-Díaz et al (2016) Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System afterOptic Nerve Injury PLoS One 11 e0162626 PMID: 27611191

David A et al (2019) Retinoic Acid Receptor-β Is Downregulated in Hepatocellular Carcinoma and Cirrhosis and Its Expression Inhibits Myosin-Driven Activation and Durotaxis in Hepatic Stellate Cells. Hepatology 69 785-802 PMID: 30055117

Ning et al (2023) Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death Dis 14 51 PMID: 36681687

Do you know of a great paper that uses CD 2314 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.